I came across your post in regard to metoforim and myasthenia. Due to taking prednisone for 5 years now with dosage from 5mg-60mg per day I was recently diagnosed with diabetes. The doctor put me on metorforim 500 mg in am and 500 mg in pm. Most of the time I skip the pm dosage. Shortly after starting metorfim my myasthenia got worse. My neurologist upped my prednisone to 60 mg daily. In the morning I feel good until I take the metorforim. What negative effects are you having from the metorfim?

Most of the people who discontinue Metformin do so because of the gastrointestinal side effects. I personally found them unbearable. Constant cramping and diarrhea.

The other thing metformin does is to deplete Vit B12... but this takes some time, and is not an instant effect.

I'd get a serum B12 run to see if you are low. Being weak and tired can be one sign of low B12.

Long term use of prednisone will deplete many things. Magnesium, zinc, and potassium, calcium and selenium.
Also folate, Vit C and Vit D.

All these nutrients may be affected by long term prednisone use.

I could not find any papers on metformin and myasthenia.

Metformin does not dramatically lower blood sugar as a rule. It might
be a good idea to get a glucometer and measure your blood sugar several times a day to see what it is doing.

sorry, been busy.
I wasnt having any negative effects regarding myasthenia.
It was just the constant stomach problems.
Not a little, all day long.
When I finally convinced my physician the metformin was torturing me, he switched me to onglyza, and within 36 hours I felt fine.
My physician did have the audacity to tell me how very few of his patients complain about metformin.
Like Im a freak or something. Only Im suffering.

on a side note, first week in nov is my last IVIG treatment, neuro feels the cellcept is working, feels I can stop the ivig.

My sister's doctor actually put her on it jsut for her bowels. Couldn't find anything else to work

Ah, I remember those Metformin days very well. Had to get off buses just to run home and go to the bathroom. Did this of YEARS.

Went on Lantus. Never looked back. But then I'm very lucky

All I do now is Levimir 18 units (sometimes 15) at bedtime. But then again, I'm a control freak about my diet and I'm also very lucky.

I found out that you eat perfectly, do everything right, but if it's your genetic makeup, etc, etc, sometimes it's not enough.

So I still try and hopefully shall continue to maintain my blood sugar as best I can.

Melody