Go Back   NeuroTalk Support Groups > >

Diabetes / Insulin Resistance / Metabolic Syndrome For discussion of Type 1 and Type 2 diabetes, insulin resistance and metabolic syndrome.

Question about Type 2 and genetics.

Reply
 
Thread Tools Display Modes
Old 06-08-2017, 10:06 PM   #1
MelodyL
Wise Elder
 
MelodyL's Avatar
 
Join Date: Aug 2006
Posts: 8,266
My Mood: Question about Type 2 and genetics.
Default Question about Type 2 and genetics.

Hi all.

I have a friend who will turn 60 soon. She's morbidly obese and has not seen a doctor in over 30 years. She's scared to death. Well, for whatever reason, she let me take her blood sugar tonight. I could not believe it. I really thought it would be high because her mom and dad (both deceased) had diabetes (Type 2) and her 55 year old sister has diabetes. She's on Metformin. The parents got it when they were in their 50's. The sister, (well I don't know when she found out).

My friend cooks and eats carbs all day. But she's never thirsty and the other day we were talking and she mentioned that she never gets up to pee during the night. I said to myself "I would love to test her, just to see what it would be".

Well, we were all sitting at Dunkin tonight. Alan went to sleep so I went out and down to the corner to meet up with my friends. I took their blood sugar.

My friend initially would not let me. I told her 'I promise to keep my face straight and not give anything away but I just want to know". I could not believe she said yes.

Well it was 127. After eating Pasta and carbs all day long. I got so excited I showed her and she was amazed. She had been afraid to find out.

Not let me ask you a question. Does this mean that she has no predisposition to be a diabetic? I mean, after all these carbs, and she's obese, she's not a diabetic?? That's amazing.

Thanks to anyone who can explain the genetics of diabetes to me. I mean I can go on the internet and read but there's all that different information and I just want to understand.

I told her 'Just because you found this out, doesn't mean you go and eat Sundaes and pizza all the time". She laughed and said "Oh I know"

Thanks to anyone who can explain this to me. I mean, both parents and her sister (who is not obese) can have diabetes and it skips her??

Melody
__________________

.


CONSUMER REPORTER
SPROUT-LADY



.
MelodyL is offline   Reply With Quote
Old 06-09-2017, 04:41 AM   #2
kiwi33
Magnate
Community Welcome Team
 
kiwi33's Avatar
 
Join Date: Jan 2015
Location: Sydney, Australia.
Posts: 2,265
My Mood: Question about Type 2 and genetics.
Default

Given the family history of your friend and the fact that she is morbidly obese, she is probably at high risk of Type 2 diabetes. Eating lots of high GI carbohydrates will not help. High GI carbohydrates are rapidly converted to glucose. This resulting glucose spike leads to a corresponding spike of insulin - this can lead to what is called insulin resistance which can progress to Type 2 diabetes.

Mutations in many genes are risk factors for Type 2 diabetes. The effect of a mutation in just one of them is usually small but this is cumulative - the more relevant genes are mutated the bigger the risk. This is because the more different abnormal proteins (coded for by the different mutant genes) somebody makes the more likely it is somebody will develop Type 2 diabetes.

You and your friend might find this helpful Genetics of Type 2 Diabetes.
__________________
Knowledge is power.
kiwi33 is online now   Reply With Quote
"Thanks for this!" says:
MelodyL (06-09-2017)
Old 06-09-2017, 02:02 PM   #3
MelodyL
Wise Elder
 
MelodyL's Avatar
 
Join Date: Aug 2006
Posts: 8,266
My Mood: Question about Type 2 and genetics.
Default

Quote:
Originally Posted by kiwi33 View Post
Given the family history of your friend and the fact that she is morbidly obese, she is probably at high risk of Type 2 diabetes. Eating lots of high GI carbohydrates will not help. High GI carbohydrates are rapidly converted to glucose. This resulting glucose spike leads to a corresponding spike of insulin - this can lead to what is called insulin resistance which can progress to Type 2 diabetes.

Mutations in many genes are risk factors for Type 2 diabetes. The effect of a mutation in just one of them is usually small but this is cumulative - the more relevant genes are mutated the bigger the risk. This is because the more different abnormal proteins (coded for by the different mutant genes) somebody makes the more likely it is somebody will develop Type 2 diabetes.

You and your friend might find this helpful Genetics of Type 2 Diabetes.
I'm telling you, I know my friend. She eats all day. All carbs. All night too. She's either the luckiest person on earth or it will hit her one day. She can barely walk, because of her knees and her feet. Won't see a doctor. Not at all. I was lucky to be able to check her sugar.

Oh well. I was like that 30 years ago. Took me YEARS to change.

Thanks much

Melody
__________________

.


CONSUMER REPORTER
SPROUT-LADY



.
MelodyL is offline   Reply With Quote
Old 06-09-2017, 11:01 PM   #4
caroline2
Senior Member
 
Join Date: May 2015
Location: Santa Monica, CA
Posts: 1,985
Default

It's amazing she's still living. I was in hospital/rehabs recently for knee issue and a young 33 yr old came into the room as a room mate, she had been in a terrible accident and had her one leg amputed at the knee...while they were attending her they found out how diabetic she was. She was on daily insulin and told me before accident she was 50 lbs heavier. Poor young girl, mother of 3 and in that bad of shape. She was quite thin at this point but so young and with these disabilities.

While nurse came in to do her blood tests daily, I asked nurse to test mine and I was always 90-100. Her readings were always like 200-300 on the meds and insulin.

She was of mexican heritage and I had heard many mexicans are diabetic, as a matter of fact Mexico has come in first over the U.S. with most obese.

A friend here who has a friend down in Palm Springs says her friend was tested at a point and BS was about 600. She is not in good health at all.

I eat very low carb diet, splurge sometimes with some pizza, but no breads etc and haven't had pasta in years.
__________________
OA onset at 18, now 79. Fibro onset at 61, Hip Replacement "mess" 72 (nerve damage, IT band damage, shorter leg). Otherwise, pretty good health.

Most important supplement: grape seed extract
caroline2 is offline   Reply With Quote
Old 06-11-2017, 02:56 PM   #5
MelodyL
Wise Elder
 
MelodyL's Avatar
 
Join Date: Aug 2006
Posts: 8,266
My Mood: Question about Type 2 and genetics.
Default

Quote:
Originally Posted by caroline2 View Post
It's amazing she's still living. I was in hospital/rehabs recently for knee issue and a young 33 yr old came into the room as a room mate, she had been in a terrible accident and had her one leg amputed at the knee...while they were attending her they found out how diabetic she was. She was on daily insulin and told me before accident she was 50 lbs heavier. Poor young girl, mother of 3 and in that bad of shape. She was quite thin at this point but so young and with these disabilities.

While nurse came in to do her blood tests daily, I asked nurse to test mine and I was always 90-100. Her readings were always like 200-300 on the meds and insulin.

She was of mexican heritage and I had heard many mexicans are diabetic, as a matter of fact Mexico has come in first over the U.S. with most obese.

A friend here who has a friend down in Palm Springs says her friend was tested at a point and BS was about 600. She is not in good health at all.

I eat very low carb diet, splurge sometimes with some pizza, but no breads etc and haven't had pasta in years.

I hear you. What has always fascinated me was the people in Samoa. They are a big people. What is the rate of diabetes among that group?

Last night we were all in our Dunkin hangout and naturally all the donuts are on the table. Donuts don't do anything for me. Never did. If I were going to cheat, I'd love a hot fudge sundae (on my birthday, I either have a Calzone or a sundae), but that's once a year.

My poor friend. Last night as she was struggling to get up off the chair, she could not walk. Her knees are SO bad. She's in such pain. She eats from stress. She's worried about her offspring not coming home and staying with the boyfriend so she's up all night till 4 a.m. and she eats.j

Not a good thing. But stress does that to a person. She once said 'If my daughter moves out I will go out of my mind".

I believe her.

Melody
__________________

.


CONSUMER REPORTER
SPROUT-LADY



.
MelodyL is offline   Reply With Quote
Old 06-12-2017, 01:30 AM   #6
kiwi33
Magnate
Community Welcome Team
 
kiwi33's Avatar
 
Join Date: Jan 2015
Location: Sydney, Australia.
Posts: 2,265
My Mood: Question about Type 2 and genetics.
Default

Melody, the incidence of Type 2 diabetes and obesity in Samoa is the highest in the world - the former incidence is more than 30%. Genetic risk factors do not seem to be important. The main risk is ready availability of cheap poor quality imported foods.

I understand your worry about your friend. Maybe you could encourage her to walk a bit more, even if it is only a bit to start with. That will help her to lose weight in a controlled way and could also could help her to deal with her stress. I am not over-weight but walk whenever I am feeling stressed - it works for me.
__________________
Knowledge is power.
kiwi33 is online now   Reply With Quote
Old 06-13-2017, 09:42 AM   #7
MelodyL
Wise Elder
 
MelodyL's Avatar
 
Join Date: Aug 2006
Posts: 8,266
My Mood: Question about Type 2 and genetics.
Default

Quote:
Originally Posted by kiwi33 View Post
Melody, the incidence of Type 2 diabetes and obesity in Samoa is the highest in the world - the former incidence is more than 30%. Genetic risk factors do not seem to be important. The main risk is ready availability of cheap poor quality imported foods.

I understand your worry about your friend. Maybe you could encourage her to walk a bit more, even if it is only a bit to start with. That will help her to lose weight in a controlled way and could also could help her to deal with her stress. I am not over-weight but walk whenever I am feeling stressed - it works for me.
She walks everywhere. I could never walk like she does. She can barely get up off a chair but she walks (it hurts her, I can tell this) about 10 blocks to her job and back again.

She must have exceptional genes.

Melody
__________________

.


CONSUMER REPORTER
SPROUT-LADY



.
MelodyL is offline   Reply With Quote
Reply

Tags
carbs, diabetes, friend, shes, sister

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
type I vs type II…. is there a reason to know? Mlhps Reflex Sympathetic Dystrophy (RSD and CRPS) 10 01-09-2015 11:42 PM
Psoriasis type question doydie The Stumble Inn 5 07-23-2012 07:13 PM
lawyer type question about working doydie The Stumble Inn 4 06-18-2012 11:22 PM
An MRSD type question! Megan Peripheral Neuropathy 11 03-05-2008 02:40 AM
PT type question lucinda Children's Health 4 10-11-2006 08:23 PM


All times are GMT -5. The time now is 03:14 AM.
Brought to you by the fine folks who publish mental health and psychology information at Psych Central • Mental Health Forums

The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider. Always consult your doctor before trying anything you read here.


Powered by vBulletin • Copyright ©2000 - 2018, Jelsoft Enterprises Ltd.
Search Engine Optimisation provided by DragonByte SEO v2.0.31 (Lite) - vBulletin Mods & Addons Copyright © 2018 DragonByte Technologies Ltd.

All posts copyright their original authors • Community Guidelines • Terms of Use • Privacy Policy