Sue... don't mean to bug you, i think this must be a painful subject but something you said (see emphasis) in this last post made me wonder... ... if i get it right, when the depression cleared, he started being strange? that sounds like the Zoloft might have triggered a manic episode. That can happen if a person has "bipolar in their jeans (genes)" ... they may be normal, or have only depressive episodes before treatment with an AD. If he was triggered into mania and cycling, he can be treated. Otherwise he will likely continue to cycle. Unmedicated mania can lead ppl right into a waaaay different "lifestyle" - taking off with no apparent reason or planning is actually quite common! I wonder if anyone in your family can be in touch with him to see how he is.

Of course i don't know in what way he was "acting strange" other than his leaving the family. Do ANY of these sx sound familiar?
hyperactivity (eg psychomotor agitation, rapid and or pressured speech), over-impulsivity (eg spending, gambling, other indiscretions), rage outbursts, mood lability, lack of focus, flight of ideas (jumping from one topic to another another so much that the listener may not even be able to make sense of the conversation), increased expansivity, decreased need for sleep or total sleeplessness for days, taking on multiple projects at once and finishing none, or being completely obsessed with a project to the exclusion of other normal activities; euphoria or dysphoria, grandiose ideas or delusions (eg believing one is a prophet or a famous person, planning ventures well out of proportion with one's abilities or means); potentially also psychotic features incl visual and auditory hallucinations, thought disturbances such as magical thinking, thought broadcasting or thought insertion).

i'm just tossing this out to you... i'm not trying to say that IS what happened... but it is a possibility, especially if there is any family history - even just of depression.

gosh i hope he is ok. i am so sorry that Zoloft took him away from you... whatever the explanation.

((( Sue )))

~ waves ~ wondering... hope i am not offending you or speaking out of place...