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bruegger84 11-17-2009 02:56 PM

hmmm ill think about it. but for now i think im gonna go the medical doctor route with the PPIs and cut back on the dosage, even if they dont let me absorb vitamins etc. cuz last time when i stopped taking them, i had all sorts of issues(headaches were worse, spasms increased)

bruegger84 11-28-2009 03:17 PM

i think i weighed the risks and benefits and decided to forgo the PPIs again for now. because i really am desperate for sleep, and i think the PPIs are interrupting absorption of my other sleep meds. it's not for lack of effort tho, cuz i tried my hardest to pull through. cuz i knew what would come back, the muscle/throat spasms and headaches. so im gonna forgo the PPIs at least for now.

and try for now to just deal with the muscle/throat spasms and headaches with what my neuro prescribed me, a muscle relaxer and possibly an nsaid or two.

as for the gaviscon ive decided to try in lieu of the PPI regimen. and maybe using the ppis on an as needed basis. because usually they say to use the Prilosec OTC delayed release capsules for 2 weeks, and you don't have to use them again for another 4 months(on the packagin)http://www.prilosecotc.com/en_US/con...ur-package.jsp

bruegger84 11-29-2009 10:44 PM

Quote:

Originally Posted by mrsD (Post 590496)
I don't believe that stomach acid enhances absorption of medications.

You may notice motility changes when going off or on SSRI drugs like Lexapro. Since this drug increases serotonin in the synapse, it affects gastric functioning for some people. Some people have nausea/vomiting on it or diarrhea. Serotonin is the main neurotransmitter in the GI tract.

Solubility in water, is the most critical factor for absorption, but even then, some insoluble things do get thru. Giving highly lipophilic drugs with a fatty meal, can help absorption of this type.

I have not been aware of drugs needing acid to be absorbed...I wonder who told you that.

In fact long term use of PPI drugs leads to gas and more reflux.
This is because the protein you eat is not digested properly and is fermented by bacteria in the intestine instead forming gas.
The gas then come back up or down depending along with diarrhea for some people. This is why those side effects are listed for those drugs. Gas coming back up as a belch, will also reflux food if it is present.


I'm wondering what all this means. i tried my best to absorb the merck with the ionizing and unionzing. it seems a bit complicated. and what if anything, my poor tolerability of aspirin has to do with this.

everytime i take aspirin, i feel like it really does a number on my throat, it's hard to describe but it causes an immediate weakening of me, along with crepitus in my throat region. and i end up having trouble sleeping the night, and so for a few days i don't feel myself.

i hate having to deal with this stuff, and having to go through doc after doc, just to have him kick me out of the office, with his payment in hand. I know that there's just this truth out there that they haven't gotten to yet.

because u know when there's something wrong, and ive known since about 7 years back and i think i can pretty much tell the difference between somatic and non somatic. hell, i even read 'house of god', in which the whole point of the whole story was that none of us are sick, we're just in need of love and I also tried to get into a hypochondriac study just to cancel out some variables.

mrsD 11-30-2009 07:28 AM

Just take my word for it.... drugs do not need acid to be absorbed. In fact the acid in the stomach can interfere with some drugs (peptide types, etc). Some drugs are enteric coated for this reason. Some nutrients do need acid environment for absorption, and acid is needed to digest protein.

Crepitus is the sound that joints make when they are grinding against each other. The clicking you hear when you swallow is from your eustachian tubes trying to equalize the pressure for the middle ear.

If you have problems swallowing, often, or feel weak all over, you should be evaluated for Myasthenia gravis. I'd suggest you read our forum here. There are several men who participate who can help you find appropriate medical interventions, tests.
Myasthenia gravis is an autoimmune disorder where the antibodies attack the neuromuscular junction, and produce weakness.

bruegger84 11-30-2009 05:12 PM

right, my doctor just ordered a cervical xray, and bloodwork as i was having trouble swallowing and he wrote that on the order. i think he was checking acetycholine values, cbc, and ck

mrsD 11-30-2009 05:38 PM

That's good. You need to know what is going on.

I hope you don't have MG tho.

bruegger84 12-02-2009 04:51 PM

Quote:

Originally Posted by mrsD (Post 595135)
That's good. You need to know what is going on.

I hope you don't have MG tho.

i just got the EMG done. this wasn't a bad EMG like i had before on my shoulder. but just a reflexive kind. it showed that i had a tendency towards myasthenia gravis. so he put me on a medicine to further confirm the diagnosis. the medicine is mestinon(pyridostigmine) 60 mg tablets. take 1/2 3 x day. then 1/2 4x day. then titrate up to 1 3 xday, and up to 4xday if tolerable. if i do well on this medicine it confirms the diagnosis. he says the side effects are as follows diarhea, nausea. then he has to do a muscle biopsy to further confirm it.

mrsD 12-02-2009 06:33 PM

Oh, my. I'd start reading our Myasthenia gravis forum now, since this is a very tricky thing to treat. There are alot of very friendly and experienced posters there to help you!

I'll be following your postings there.

bruegger84 11-29-2010 05:56 AM

yah ive started up on gaviscon again, since it was pretty helpful before about a year ago. its very chalky so anything, that leaves a weird film in my mouth isnt too pleasant, but i guess ill hafta deal with it if it heals up.

there are two types of gaviscon, i think the gaviscon regular which is made with magnesium trisilicate, and then the gaviscon extra strength whihc is just made with a different magnesium(carbonate) at a different amount.

i still haven't gotten the biopsy, as i had to swithc primary care. and in general do not believe i have MG. but i will in teh future look into it, after i get the other problems solved. supposedly MG can affect respiratory muscles or opening as well. anyways, thanks for the help on that

bruegger84 12-09-2010 01:24 AM

i also have been trying the ppis again, as my doctor recommeneded to try it again to see exactly what happens. the first day i was fine, i actually felt really good and responded well, the second day wasn't that good, but i was still feeling ok. the third day after taking my third dose, i was almost panicking, and having anxiety and a rapid heart beat. so this in particular is what happens when i go on the ppis, so i generally stop taking them do to this effect.

I mean if i could take these ppis in seperate doses and then stop taking them, and then take them again, that would be good, but probably not good for my health, or either that or i hafta discuss it with a doctor. they do have some sort of benefit. i think the real reason why ppis dont work with me, is they screw up your intestinal tract, so that serotonin doesnt get produced through there. and i can actually feel myself getting hungrier from the ppis, maybe cause less serotonin is produced due to the lessening of acid. but that is just a theory.


i still am actually going to try to eat less. and hopefully that works things out, i already feel slightly better, from not eating as much. but still have the other symptoms which ill get checked out when im back on insurance, i actually have to get on masshealth, or on my parents insurance for antoher 3 months, until i get the masshealth

but more specifically eating alot isnt bad, it's just bad if u eat alot all at once. in other words, if u eat till your extremely bloated, or full. i know have to adjust that, to eat till i feel at least contented, and then leave the dinner table. it's a simple philosophy, and so far i havent lost weight, but my symptoms are somewhat less.


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