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Fibromyalgia and Chronic Fatigue Fibromyalgia syndrome is a widespread musculoskeletal pain and fatigue disorder which generally occurs in the muscles, ligaments, and tendons – the soft fibrous tissues in the body. This forum is for fibromyalgia and Chronic Fatigue Immune Deficiency Syndrome (CFS/CFIDS). |
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06-04-2007, 01:14 AM | #1 | ||
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My view is he is missing a subset of fibro. That is the people that have fibro due to autoimmune disorders.
I have been through the anti depressants and none of them work. And the dose was to the level that i started to get serotonin syndrome. I do not have depression. My fibro is due to damage by autoantibodies and high levels of INTERLEUKIN 6 from castleman's disease. I do not believe that fibro is one disorder i believe that it is a group of disorders. in many ways it is like MS or diabetes In MS you have 4 different types. An diabetes you have type 1 and type 2 I believe that my fibro is due to low levels of GABA and/or Glycine in the CNS The best meds i have found for my fibro are Gabapentin and a over the counter GABA supplement. TO THIS DAY I HAVE DOCTORS THAT STILL WANT TO PUT ME BACK ON ANTI DEPRESSANTS. even through they do not work and the side affects are worse then the fibro. why because most doctors are trained that anti depressant are the best meds for fibro. even if they dont work. |
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06-04-2007, 05:01 AM | #2 | |||
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Wisest Elder Ever
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generating questions.
It was difficult for me to condense the information presented by Dr. Clauw which was a power point type thing... my syllabus does not have text, only power point slide copies. First off... the main thrust of his lecture was the definition of fibro. This syndrome is basically an overresponse by the nervous system to sensory and pain stimuli. In a fibro person (who inherits this tendency)...it is like a radio turned up to full volume all the time. In normal people there are feedback loops in the brain to turn DOWN stimuli, after they are perceived. In fibro this does not happen. So ALL stimuli tend to be preceived as noxious. The facilitator compounds listed: Quote:
For example a substance P antagonist is in phase II or III trials right now. Its target is depression, but it may prove helpful to fibro patients. I posted this on our Depression forum. The inhibitor compounds: Quote:
The pain loop is a complex circuit of ascending and descending fibers, and is really too complex to go into here. Now if you look at the Most valuable treatments... gabapentin and Lyrica are listed as primary interventions at this time. Both do NOT affect GABA per se...here is there pharmacology: Quote:
I would like to comment to Augoldminer...that some patients over the years on this board and Braintalk, have seen improvement in MS type symptoms and fibro by going on the gluten free diet. Gluten is a primary trigger for autoimmune issues in some patients. Some even do casein and corn elimination diets and find response to those as well. Autoimmune issues can be triggered by viruses, and vaccines as well. And they may exist in patients IN ADDITION to fibro..often people have several issues, which may or may not overlap. Dr. Clauw believes that fibro is a genetically transmitted syndrome, and does not occur in certain people, because they lack the genetic error that allows the pain receptors to go into overdrive. That is his opinion at this time. L-glutamine is thought to inhance GABA functions, and I have seen Inositol also recommended for this (it improves glucose utilization in the brain). While Dr. Clauw does not work for drug companies, he did suggest that the combination SSNi and SSRi drugs help more than plain SSRi types. The new drug Milnacipran is very effective with very few side effects now used in other countries. It is very close to FDA approval here and may be available in one year or so. I will also add that Dr. Clauw said that Fibro is the "last great frontier" that the drug companies are looking towards... they want to find effective pharma agents because...well, frankly there is a huge financial gain to it. He predicts "blockbuster" agents in the near future. Here is the link to the new agent that may help with blocking excess substance P: http://neurotalk.psychcentral.com/sh...ad.php?t=19026
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Last edited by mrsD; 06-04-2007 at 06:51 PM. Reason: fixing error in grammar |
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03-09-2011, 06:13 PM | #3 | |||
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