Quote:
Originally Posted by jacko
Hi bucky, I have been taking tramacet for about 1 year as well as arthotec and effexor, for the past 6 months I have noticed extremely large bruises all over my body, I talked with my dr as well as the pharmacist and they say different things. the dr says it might be the gluclosamine i take for my joints and the pharmacist says it might be the arthotec, which is a blood thinner, i have recently cut down on this but am still bruising alot.I have also heard that tramacet can cause liver damage which scares me .how will you know if this is true. If I dont take these pills I have alot aof pain , I have degenerative disc disease and pain in me legs when i walk so they take the edge of but the pain is always there. any wise words or suggestions. thanks Jacqueline
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SSRIs--- which Effexor has this action in addition to the SSNi effects, lower platelets in the blood.--Combined with the Diclofenac in the Arthrotec you could have an additive effect. I really don't think it is the glucosamine.
If you type in Effexor bruising into Google there are many hits on other boards.
I think it is the combo for you however.
Also Arthrotec contains Cytotec, which may affect clotting. Here is a paper describing using this drug alone to help with
peripheral vascular disease--
Quote:
Methods Find Exp Clin Pharmacol. 1998 Jun;20(5):439-45.Click here to read Links
Treatment of peripheral vascular disease with misoprostol (Cytotec): a pilot study.
Goszcz A, Grodzinska L, Kostka-Trabka E, Bieron K, Slawinski M, Jachym R, Ochmanski W.
Department of Clinical Pharmacology, Jagiellonian University Medical College, Cracow, Poland.
Misoprostol, the oral analogue of alprostadil, was used to treat 20 patients (aged 40-60 years) with peripheral arterial disease (PAD) according to Fontaine's classification at stages IIa and IIb. All patients received 200 micrograms of misoprostol 3 times a day during a month. The therapy with misoprostol resulted in clinical improvement in all patients. Elongation of pain-free (before treatment: 129 m +/- 78 m; after treatment: 214 m +/- 109 m) and maximum walking distance (before treatment: 304 m +/- 169 m; after treatment: 471 m +/- 264 m) was observed. At the same time, a shortening of the duration of pain was noted (before treatment: 100 sec +/- 37 sec; after treatment: 71 sec +/- 23 sec). The ankle/arm pressure ratio (AAPR) and arterial blood flow increased in both limbs after 4 weeks of treatment. Activation of the fibrinolytic system was seen in the course of therapy (shortening of euglobulin clot lysis time (ECLT) and increase in t-PA activity). The platelets became less sensitive to ADP and collagen after intake of misoprostol. The results justify administration of misoprostol as a new therapeutic agent for the treatment of patients with PAD.
PMID: 9701783 [PubMed - indexed for MEDLINE]
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SSRis can cause bleeding by themselves.
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Weezie looking at petunias 8.25.2017
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09-14-2007, 11:01 AM
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