NeuroTalk Support Groups - Gallbladder Issues...

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I will start up the magnesium again for sure, I used to take it all the time, but I got lazy when the doctors gave me other medications that I had to take. It all gets to be a really big hassel. Yes, that is my biggest fear and why I won't get the gallbladder out. I am terrified that the surgery would do nothing to get rid of the pain. You have given me wonderful suggestions and hopefully one of them will be the key to getting this back in order. I won't be able to see the GI doctor though for at least another two weeks, because the one I trust and go to works in Maryland and I live in Florida. That seems to be the way it goes with all of my doctors, the ones down here can't help me. They say I'm not an adult yet, but at the same time I don't fit into pediatrics.

Well, I am confused. You list on your first post that you take Celebrex? Now you also take Advil too?

You should not be taking these two together. Celebrex is an NSAID too.

I'll clarify what I said:
Taking Cipro (antibiotic) with Advil may create neurological damage.

Here is a list of the types of damage Cipro can cause in some people:

Quote:

The Committee on the Safety of Medicines and the FDA warn that central nervous system adverse effects, including seizure risk, may be increased when NSAIDs are combined with quinolones.[20][88] The interaction between quinolones and NSAIDs is important, because it has the potential for considerable CNS toxicity. The mechanism for this interaction is believed to be due to a synergistic increased antagonism of GABA neurotransmission.[43]

from:http://en.wikipedia.org/wiki/Ciprofloxacin

I think you and your parents should read this link carefully.
And discuss this with your doctors. When people start going to specialists... today they do not always keep in touch with each other and serious overlaps in treatments or serious side effects are not shared and the patient suffers for that.

This quote is from the Levaquin page of Wiki. It goes into more detail:

Quote:

In 2004, the FDA requested new warning labels to be added to all of the Fluoroquinolones, including levofloxacin, regarding peripheral neuropathy (irreversible nerve damage),[51][52] tendon damage,[53][54] Heart Problems (prolonged QT Interval / Torsades de pointes),[13][51] Pseudomembranous colitis,[55] Rhabdomyolysis (muscle wasting),[56][57][58] Stevens-Johnson Syndrome,[59] as well as concurrent usage of NSAIDs contributing to the severity of these reactions.[51]

from http://en.wikipedia.org/wiki/Levofloxacin
Also using this family of drugs in pediatric patients, is risky. And recommended only for infections not responding to other agents.

I also see, on your PD post, that you have a previous diagnosis of LYME disease?

I am concerned for you because of this new posting of adding Artane to your list of medications. The interaction with Bentyl is significant. Your GI doctor gave you that, and now a neurologist wants to add in another drug that works in the body the same way? You should not taking them together. And you should not be using Celebrex and Advil together.

Please study up on the internet about your medications.
Rxlist.com and the drug checker at Drugs.com are excellent sources of information.
http://www.drugs.com/drug_interactions.html

Quote:

Originally Posted by samanthahorn94x (Post 848486)

Again thank you, is vitamin D12 of any value because I take 1000 IU of that a day? Also can taking advil on a regular basis cause more damage to the gallbladder? I am aware that it is not the best thing I should be taking with my other mediations. However, I have re-dislocated my left patella, which I had surgery on a few years ago, and have been taking advil to alleviate the pain and reduce the swelling. I am going to physical therapy for that now, and see the surgeon again in a few weeks to see if they need to redo the surgery.

Thank you, I know of the celebrex and advil issue I am just at a loss of what to do. I re-injured my left patella, which I had surgery on about three years ago. On the celebrex alone the swelling would not go down, when taking advil alone the pain everywhere else was not okay. I want to thank you for making me aware of the significant side effects between the Bentyl and Artane, there is no way I will be starting this medication before talking to both the neurologist again and the GI Doctor. Yes I had Lymes when I was about five years old, I lived up North at the time, it was caught early enough that I was given the standard round of a moxicillian for about 45 days. After that everything was fine up until a few years ago... I had the Lymes checked repeatedly and they say that I do not have enough bands showing up on the blood work for it to be considered Lymes again. Plus I'm pretty sure if it was that I would have seen a drastic improvement when they were treating me for Lymes... Right?

It is possible to still have that LYME

http://www.ajnr.org/content/30/6/1079.full

Doctors do not agree at all about this disease.

Since you had a diagnosis of Lyme in the past, you should be
considering it now as well. Neurological Lyme exists..getting it diagnosed and treated is difficult however.

I know I've been tested multiple times for it and I was considering doing it again. The problem is from my experience, doctors jump to treatment before getting definitive proof of what the disease is. I had a false positive for lupus like a year and a half ago and was put on high dose steroids for a month before they retested my blood and found out that it wasn't lupus. With the Lymes if they just want to start treating again then they would be going straight to the IV meds and that worries me, because if it is not the lymes then I was reading up on it and the meds can box your kidneys. I am aware that everything has side effects that just seems a bit extreme for a possibility... you know?

With all the things--

--you've been listing through these threads (this one especially), and given that you are so young, you might want to get a work-up from scratch at a major teaching hospital or medical center.

Not that you shouldn't bring results of previous tests and a concise, written medical history with you to this (including your medications over the years)--a fresh set of eyes, or several sets, might help, and some more elaborate testing may be available.

What I'm seeing from all this is someone whose symptoms may at this point be very difficult to separate from those caused by drug interactions, and someone who for whatever reason has had a very scattershot approach to testing/diagnosis. I'm finding it difficult to keep your situations straight and organized in my head, and I bet a lot of doctors would have a similar difficulty.

All drugs come with trade-offs.

As far as kidney problems, taking two NSAIDs together is very
hard on the kidneys.

http://en.wikipedia.org/wiki/Non-ste...lammatory_drug

Quote:

NSAIDs are also associated with a relatively high incidence of renal adverse drug reactions (ADRs). The mechanism of these renal ADRs is due to changes in renal haemodynamics (blood flow), ordinarily mediated by prostaglandins, which are affected by NSAIDs. Prostaglandins normally cause vasodilation of the afferent arterioles of the glomeruli. This helps maintain normal glomerular perfusion and glomerular filtration rate (GFR), an indicator of renal function. This is particularly important in renal failure where the kidney is trying to maintain renal perfusion pressure by elevated angiotensin II levels. At these elevated levels, angiotensin II also constricts the afferent arteriole into the glomerulus in addition to the efferent arteriole it normally constricts. Prostaglandins serve to dilate the afferent arteriole; by blocking this prostaglandin-mediated effect, particularly in renal failure, NSAIDs cause unopposed constriction of the afferent arteriole and decreased renal perfusion pressure. Horses are particularly prone to these adverse affects compared with other domestic animal species.

Common ADRs associated with altered renal function include:[3]

Salt and fluid retention
Hypertension (high blood pressure)

These agents may also cause renal impairment, especially in combination with other nephrotoxic agents. Renal failure is especially a risk if the patient is also concomitantly taking an ACE inhibitor (which removes angiotensin II's vasoconstriction of the efferent arteriole) and a diuretic (which drops plasma volume, and thereby RPF) - the so-called "triple whammy" effect.[21]

In rarer instances NSAIDs may also cause more severe renal conditions:[3]

Interstitial nephritis
Nephrotic syndrome
Acute renal failure
Acute tubular necrosis

NSAIDs in combination with excessive use of phenacetin and/or paracetamol may lead to analgesic nephropathy.[22]

So you are taking TWO of these drugs together. Not safe for you.