Hi, there. Thanks for taking the time to read this. I'm desperate for some guidance.

I'm a 40 year old male with what appears to be some sort of acetylcholine dysregulation. I first contracted symptoms 15 years ago which were both constant tachycardia, very severe depression, nonstop panic and a 'revved' feeling which I assumed was adrenaline.

Long story short no psychotropic medications resolved the tachycardia nor any of the mental symptoms. I tried everything until I discovered phosphatidylserine complex (including ethanolamine and choline) addressed nearly all the symptoms: slowed my heart down reasonably, gave me clarity and I was able to go back to work.

Fast forward 10 years later or about 3 weeks ago I came down with a chest infection and took a Z-pac. The third night of use I was overcome by a panic attack and all of my old symptoms returned. The phosphatidyl serine complex no longer slowed down my heart and my panic returned. However, if I do not take it at all during the day things are worse. It just seems like my ACh is completely unregulated right now. Just a guess.

Sorry for the long winded post, but: any idea what could be happening? Autoimmune reaction? Why the weird reaction to a med that worked for > 10 years. I have had severe digestive problems over the years as well as a sensitive immune system. I wish I just had straightforward depression or anxiety.

Sorry that I can't help you figure this out but wanted to say 'hey' and welcome to the site.

Lots of caring and support here. I'm sure there will be others behind me that can give you information on this.

Take care of yourself

Debi from Georgia

Thanks, Debi! I really appreciate it!

Hi,

I think I may have an idea what is wrong, I'm not a Dr but I just want to help.

It sounds like you may have the condition postural orthostatic cardiac syndrome or some type of dysautonomia both of these can be linked to ACH as many people with pots or dysautonomia are treated with mestinon ( a drug they use with myasthenia gravis).

I would like you to first Google pots place and then Google DINET its a forum for people with Pots / dysautonomia. I think this may give you the answers you've been looking for.

Also take a look at my blog the address is in my signature. There is a post on there called A constant state of panic.

Feelings of anxiety and panic with tachycardia are quite normal in pots / dysautonomia that's what got my attention in your post.

I hope this helps
Rach x

I too have the same symptoms but with rather bad dysphagia and hands drop things and had 3 attacks of acute weakness that over 1-3 hours of use led to paralysis . I'm neg for mg antibodies. I'm on mestinon which fixes the dysphagia . I also have had racing heart for months lack of ability to sweat dry eyes mouth and nose and dizzy when I stand up . Neuro says its some sort of myasthenic type condition.