[northernlights]

I was re-reading this article which says that DQ7 is a celiac gene too, and noticed something that looks to me like DQ1 is a celiac gene too:
http://www.clinchem.org/cgi/content/full/44/8/1755
"Eight of the 122 CD patients lacked both the heterodimer and the DRB104 alleles; therefore, we further screened the DQB1 locus to investigate if other alleles were present in association to CD (2)(14). Two of these eight CD patients showed the DQ2 molecule (DQB10201 allele in heterozygosis); but one of them carried also the DQB10501 allele, also found in Sardinian patients to be associated to CD (15); four showed the DQ7 molecule (DQB10304 or DQB10301 alleles). Another patient carried the DQ8 molecule encoded by the DQB10302 allele, and the remaining patient had the haplotype DQB10501 in homozygosis (15). The DQ8 molecule seems to be an alternative to DQ2 in influencing susceptibility towards CD, being present in up to 20% of celiac patients not bearing of DQ2 in the Mediterranean area (2)(14)(16). Our data do not support an earlier finding that HLA-DQ7 is a nonsusceptible molecule (2). In fact, DQ7 was present in 50% of our CD patients in the absence of the heterodimer and of the DRB104 alleles. Because the DQ7 molecule is very similar to the DQ8 molecule, it could alternatively present similar gluten-derived peptides to restricted T cells (17). DQ7 has been detected in a few CD cases in the absence of DQ2 but in association with the DRB104 alleles (18). "
and they have a reference http://www.ncbi.nlm.nih.gov/sites/en...t=AbstractPlus what is DQA1*0101,DQB1*0501 ?

what do you say?

nora