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Old 10-27-2009, 09:59 PM #1
LJmom LJmom is offline
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Join Date: Sep 2009
Posts: 7
10 yr Member
LJmom LJmom is offline
Junior Member
 
Join Date: Sep 2009
Posts: 7
10 yr Member
Default understanding gene test results

I have a lot of questions about test results, don't I?! Your help has been invaluable.

My daughter had gene testing through Enterolab (cheek swab), results:

HLA-DQB1 molecular analysis, allele 1: 0202
HLA-DQB1 molecular analysis, allele 2: 0503
Serologic equivalent: HLA-DQ 2,1 (subtype 2,5)

EnteroLab's explanation said that she didn't have the main HLA-DQB1 genes predisposing to celiac (0201 and 0302), but she had two that predispose to gluten sensitivity (any DQ1, DQ2 other than 0201, or DQ3 other than 0302). Therefore each parent must have one copy of the gene. DQ5 is a subtype of DQ1.

I had gene tests through a blood test and the results said:

DQ2 (DQA1 0501/0505/ DQB1 02XX) - negative
DQ8 (DQA1 03XX, DQB1 0302) - negative
Greater than 95% of celiac patients are positive for either DQ2 or DQ8.

I'm struggling to know if I was even tested for the same things my daughter was, and which specific genes I do have, since apparently her test was more specific to genes that predispose to gluten sensitivity and mine only looked for those that predispose to celiac?? My best guess is that these results are telling me that I don't have a DQ2 or DQ8 gene, so the gene my daughter got from me must be the DQ1 aka DQ5. But I'm pretty confused.

Thanks.
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