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Old 04-29-2010, 12:24 PM #11
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Found the chart, it is at page 14 here : http://www.biotoxin.info/docs/Gordon..._RS_9_5_08.pdf

note the repeated mention of gliadin antibodies there.

Here too:
http://aboutmecfs.org/Conf/AACFS04Shoemaker.aspx

I have not studied these articles, i have just googled them becasue I knew about them from other discussions. I learned that HLA DR is also something to consider, not just HLA DQ.
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Old 04-30-2010, 09:20 AM #12
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That first website doesn't make any sense to me...I never heard of DR anything, so I guess we are even!!! I have read a lot about HLA-DQB or HLA-DQA, maybe it's the difference in our countries.

If you can explain it to me, I would love it. If you can figure out where I stand in your numbers...that would be great!!
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Old 05-01-2010, 11:10 AM #13
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Hi,
we mostly talk about HLA DQ types in regard to celiac....

But you only need to read a few articles on celiac genes until you stumble upon the concept DR.
I had wondered about HLA DR for some years, and noticed it could be used to differentiate between the different DQ types (like between DQ2,2 which is less celiac prone and has a different alpha chain, and DQ2,5 which is the main cleiac gene and has 0501 in hte alpha chain)
A very good chart is at wikipedia HLA DR

I stumbled upon some postings i another forum, googlieng something about mold, ehich is often discussed in lyme forums. I think it was C3a. They discussed mold susceptibility and HLA DR genes.
Not so long afterwards, someone turned up on the cleiac*forum with a gene test result that was totally different form the standard HLA DQ format, and I posted I had seen something like that on another place and it was about mold snesitivity. And, there were others who chimed in, that they had suspected mold issues and found that info interesting.

Now with my gene test results I have some DR types to consider. I still think I need another test to narrow down the HLA type, since the enterolab test is done by serology and cannot differentiate enough as far as I know.

With you, you probably got a PCR test and it probably means DR13 and 15, DR52 and 51 and you can look up things on the charts and DR pages.

You can also google shoemaker rosetta hla and find some more links, and maybe google extreme mold avoidance for more links. **
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Old 05-01-2010, 07:07 PM #14
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Well, I guess I am too simple minded, I can't make nothing out of all that scientific mumbo jumbo..sorry.
My gene testing doesn't have any of the DR numbers, and they won't be doing any further gene testing on me, not to my knowledge. Thanks for helping though.
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Old 05-02-2010, 08:51 AM #15
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Of course, they would not do any more DR testing on you since they already have the beta chains results, at least for celiac testing.
If you wonder about mold sensitivity, or lyme disease, (= inability to get rid of neurotoxins) that would be another question.

Well, when reading about celiac, often one runs into the concept DR.

The best place to start is at http://en.wikipedia.org/wiki/HLA-DR

Now there is an explanation somewhat below the middle of this page:
http://www.enabling.org/ia/celiac/cel-hla.html
like DQ2 is also DR3, and DQ8 is also DR4.

Now this one is from 1994:
http://www.sciencedirect.com/science...301eebd3e98c32
note they still wonder about DQ8, which here is DR4.
also, now we know the 05* alpha chain of DQ2,5 trans is the celiac part of this DQ2 gene, and that is why they do alpha chain testing as per reports on the celiac forums. Some with only 05* in the alpha chains have been diagnosed celiac now. DQ2,2 alone, without DQ7,5, is not so prone to celiac.

http://www3.interscience.wiley.com/j...TRY=1&SRETRY=0 more DR
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Old 05-02-2010, 02:07 PM #16
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I do wonder about mold sensitivity. I live in a basement apartment, and I do see mildew on the walls sometimes. So the issue has come up in my mind.

I have been on a yeast free diet now for 2 months...and really am doing better, finally. I also know I can't eat fungi foods, mushrooms made me sick long before I knew about gluten and all this. When I finally gave up peanut butter, I felt better too. I do love my peanut butter, can't pass it in the store without wanting to put it in my cart still!!!

The last link, I can't open, it says I need to enable cookies on my computer. I have a 1 week old computer, and have not figured it out yet...takes time!!!

Honestly, I don't think I can wrap my mind around all the DQ, DR's and such. Thank you for trying to explain though...some of us are just so dense! How do you come to the conclusion that I might be DR15? I want to read about all this stuff.
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Old 05-05-2010, 11:02 AM #17
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I tried my last link, and I got the same cookie message!
I must have surfed there from another site... I will look at the history in my eeepc.
I remember it was another article where they threw in DR together with DQ.

About the mold, I keep reading in the lyme forums that in afterthought, mold was a huge issue. Some people got sick from moldy sleep number beds.
I was in the U.S. recently, and several hotel or motel rooms smelled slightly moldy, I guess it is the damp climate (Florida) and other issues.

about your DR types and the mold:
I read several of the charts on the wikipedia DR page, and the 0603 is your mold sensitive gene, as far as I can read the charts.

Now on http://www.biotoxin.info/docs/Gordon..._RS_9_5_08.pdf there is a chart on page 14 and it looks like you are mold susceptible, like they write about on the webpages, and forums. Even lyme is hard to fight according to the charts.

I wrote down: 0603= DR13 and DR52
0602 = DR15 and DR51
and according to that chart you also use DQ, it is in the second column.
So it is 13-6-52
15-6-51
but of course we do not have the actual DR tests, this is just from the charts.
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Old 05-05-2010, 09:44 PM #18
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I can not get into that link either...very weird, but it will not open.

I think I have had problems with mold for years, at least with fungus foods and such. I have issues with chemicals too.

I will see what I can learn about this DR stuff...so much to learn!
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