Thanks. I will try to get the total IGa test from my primary care physician when i get the results of the IGa/IGg Gliadin and Transglutaminase.

it doesn't work that way, it has to have been ordered. See if you can get the doc to call the lab and have them add that test, if they still have your blood speciman

I had the test last Friday. The lab said the result will be sent to my doctor this coming Monday or Tuesday.

Can I take the total IGa test separately when I get another request from the doctor?

--from any blood sample, but has to be specifically listed--it's not a "standard" test.

You can certainly tell the doctor why you think it should be done--and point him/her to the Gluten File if you need to for papers that explain why a low total IgA may skew the results of other celiac blood tests.

Hi. I got my IGg and IGa Gliadin and Transglutaminase results today. The results are as follows:

Deaminated Gliadin Abs, IgA : 2 (Negative is from 0 - 19)
Deaminated Gliadin Abs, IgA : 3 (Negative is from 0 - 19)

Transglutaminase IGa : <2 (Negative is from 0 - 3)
Transglutaminase IGg : <2 (Negative is from 0 - 5)

There is a paragraph below the Transglutaminase result that reads:

Tissue Transglutaminase has been identified as the endomysial antigen. Studies have demonstrated that endomysial IgA antibodies have over 99% specificity for gluten sensitive enteropathy.

I was unable to get the total IGa test. With my results, do you think it is still necessary to get the total IgA test, or are my numbers conclusive of being not celiac/gluten intolerant?

I read just now on the Gluten File link that the Gliadin test should not be substituted with deaminated gliadin when you have neurological symptoms. But, the laboratory clinic where I (always) go, used deaminated gliadin (without informing me).

In the protocol of medically acceptable diagnostic tests and results, is the "deaminated gliadin" reliable enough to be conclusive for patients with neurological symptoms?

Thank you for your inputs.

Mary

--regarding that question.

Dr. Hadijvassiliou's work seems to suggest that many people with neurological presentations of gluten problems, with or without concommitant gastrointestinal symptoms, may only show up with a isolated abnormal anti-gliadin IgG and/or anti-gliadin IgA; this may be due to the fact that the anti-transglutaminse IgA is the test for which abnormal figures are most associated with villous atrophy (you probably ran across this in the Gluten File) and such people do not typically have large-scale atrophy (or at least, not yet). There's also the suspicion that people who present that way may have a different genetic profile--HLA-DQ1, as opposed to the HLA-DQ2/DQ8 types more closely associated with celiac.

But then again, as many as 20% of people with biopsy-proven celiac show up negative on the anti-IgA tranglutaminase.

The tests results you've listed certainly don't constitute a definite bell-ringing diagnosis. But there's enough variability in the tests to say it's not an absolute negative, either. You could always try a gluten-free trial just to see if things get better symptomatically--no one needs to give anyone permission for that.

Well, I think, getting a gluten-free diet should be the way to go... This will be hard for me. I dont know where to start, but getting a relief from my PN symptoms will be the best motivation for me. Oh God, I am willing to try everything just to give me relief from this pain.

Thank you.