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Old 10-29-2014, 04:18 PM #1
EmmasMom2 EmmasMom2 is offline
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Confused HELP interpret blood test results for Celiac

Hello, can anyone help me understand the attached results? They are for my 6yr old daughter.
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Old 10-29-2014, 05:59 PM #2
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Welcome EmmasMom2.
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Old 10-30-2014, 03:43 AM #3
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Originally Posted by EmmasMom2 View Post
Hello, can anyone help me understand the attached results? They are for my 6yr old daughter.
one is positive, and that is all you need. though they only performed 2 out of all the tests that they should have.
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Old 10-30-2014, 05:46 AM #4
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Default The IgA transglutaminase test--

--is the most specific (though the least sensitive) for frank celiac (the anti-gliadin tests, which I don't see here, are more sensitive but somewhat less specific and may be associated more highly with non-celiac gluten sensitivity).

The IgA anti-glutaminase test is also the one most closely correlated with villous damage of the small intestine--it is likely that if there was an endoscopy, there would be evidence of flattened villi.

In any case, she needs a gluten free diet. This will mean high vigilance, as gluten sneaks into many things as a filler or binder; it's doesn't just mean giving up bread products. And all first degree relatives should be tested for celiac as well.
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Old 10-30-2014, 10:57 AM #5
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--is the most specific (though the least sensitive) for frank celiac (the anti-gliadin tests, which I don't see here, are more sensitive but somewhat less specific and may be associated more highly with non-celiac gluten sensitivity).

The IgA anti-glutaminase test is also the one most closely correlated with villous damage of the small intestine--it is likely that if there was an endoscopy, there would be evidence of flattened villi.

In any case, she needs a gluten free diet. This will mean high vigilance, as gluten sneaks into many things as a filler or binder; it's doesn't just mean giving up bread products. And all first degree relatives should be tested for celiac as well.
So you think she should have an endoscopy done? I was thinking she was gluten sensitive but not have celiac. Would you agree?
We are going to a GI Specialist tomorrow, what questions should I have him answer and/or should I request more tests?
Thank you so much for your response!
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Old 10-31-2014, 06:11 AM #6
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Default Given that test result--

--it's likely she has celiac and some degree of villous damage.

There's probably no need for an endoscopy given the test result, unless someone wants to document to the "gold standard". The problem with many GI people who do endoscopies to take villous samples is that the villous damage is often patchy, especially early in the disease course, and many don't take enough samples or take them from the right areas (far into the small intestine, not just in the duodenum).

She should be on a gluten-free diet. And I'm betting there would be at least one more positive test result among the first degree relatives--maybe more.
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Old 10-31-2014, 08:00 AM #7
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Default Retest...

When her doctor's office called about the results they told me the doctor wants to redo the test in a month because it came back inconclusive. I don't understand the need to wait a month. We have an appointment with a GI specialist today so hopefully they will see what you do! Even if they don't, I will start her on a gluten free diet and see if it helps her. I just want her to feel better! Thank you for your responses I greatly appreciate it.
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