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Old 01-24-2015, 12:24 AM #1
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Default gs221

I have this bad gene.
Does that mean I have celiac?


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20120109 Geno time
Autoimmune disorder risk in Europeans This genoset tags the DQ2.2 haplotype in Europeans, and thus increased risk gluten intolerance and for autoimmune disorders such as celiac disease.

Sorry, newbie trying to figure out 23 and me.
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Old 01-24-2015, 12:44 AM #2
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I just saw your message and wanted to reply even though I don't know the answer to that I'm sorry baba, but I was talking to my daughter about the 23 and me genetic testing yesterday.

We were talking about other conditions specifically and she told me she'd just read on an Australian Coeliac Org site that 1 in 70 Australians have Coeliac Disease and 4 out of 5 of those actually with Coeliac do not know that they even had it.

I looked it up because I was shocked at the numbers and thought she'd got them wrong.
http://www.coeliac.org.au/uploads/65...oCTMACFull.pdf
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Old 01-24-2015, 08:03 AM #3
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Default The DQ2, DQ8 and possibly the DQ1 HLA halotypes--

--are among those that have a higher incidence of celiac among those possessing them, but it is not proof positive you have celiac; many with these genetic profiles (the DQ2, in particular, is very common among Europeans) do not have celiac.

Northern Europeans, specifically, are known to have a high incidence of autoimmune disorders anyway--rates of MS are higher among them, for example.

The DQ1 halotype is interesting in that there's been some work done, mostly by Dr. Hadijvassiliou from Finland, indicating that this particular group may be more likely to have non-gastric manifestations of gluten sensitivity, including neurologic manifestations like gluten ataxia or neuropathy.

Last edited by glenntaj; 01-25-2015 at 07:21 AM.
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Old 01-24-2015, 08:45 AM #4
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This link give some more information and a further link to look at for your named gene.

http://mthfr.net/forums/topic/gluten-and-23and-me/
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Old 01-24-2015, 10:34 AM #5
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Default gs221

Thank you.
I am specifically wondering if this mutated gene gs221:

Autoimmune disorder risk in Europeans This genoset tags the DQ2.2 haplotype in Europeans, and thus increased risk gluten intolerance and for autoimmune disorders such as celiac disease.

Could it mean that I have the non-gluten sensitivity. I have tried to go gluten free several time since developing neuropathy and now have small fiber neuropathy. I was wondering if this could be a root cause, or just part of something contributing more.

TIA
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Old 01-25-2015, 06:00 AM #6
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Writing as somebody whose day job includes immunology and apologies if this is a bit technical:

Gs221 is a variant (an allele) of a protein called HLA-DQ2. The HLA proteins occur in two general forms - Class I and Class II. Class I HLA proteins are important in helping the immune system to take care of virus infections.

Class II HLA proteins (like HLA-DQ2) have a different job. They present fragments (peptides) made by pathogens to a class of cells called helper T cells. When that happens helper T cells get activated - they can help B cells, which make antibodies, and other kinds of T cells to get rid of the pathogen which made the peptide - this is a good thing.

However, sometimes the immune system makes a "mistake" - a normal peptide, from a protein made by healthy body cells, on a specific Class II HLA allele, can "trick" helper T cells into "thinking" that peptide came from a pathogen - this mistake is the basis of most auto-immune diseases, including coeliac disease. Type I diabetes (probably the most common auto-immune disease) is another example - alleles of many Class II HLA proteins are known risk factors for it.

I hope that this is not too confusing.

The important message is that genetics is not destiny - just because you have inherited Gs221 does not mean that you are doomed to coeliac disease - your health professional care team should be able to advise you about this.

All the best.
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Old 01-25-2015, 11:05 AM #7
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There are studies, from 1999, about "acquired" gluten intolerance.
They involve the actions of NSAIDs on the intestinal mucosa, and the blocking of Cox-2 cytokines. These cytokines prevent some peptides in food from passing thru the mucosa and entering the circulation. So blocking Cox-2 is not good for the mucosa.

It is possible this genetic flaw, works in tandem with this NSAID triggered event to provide peptides for the immune system to attack. This would explain why some with this flaw develop problems and others not. NSAIDs used to be on RX, and since going OTC are used heavily by people, and recommended by doctors still. After reading the NSAID studies long ago, I could see how acquired gluten sensitivity works, and today it seems to be on the rise especially. Ibuprofen and naproxen are the two most commonly used ones today OTC.
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