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Old 06-16-2015, 10:12 AM   #1
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Default Test results

So my 3 year old has been fighting chronic constipation and bloating problems her whole life. She literally fills up her whole intestinal tract with stool to the point she gets sick and stops eating. When that happens she has to be flushed with multiple enemas over a week to clean her out. Laxatives do not work. Miralax is totally ineffective, as is milk of mag. She is currently on 8 squares of exlax per day and it is losing its effectiveness as well. We have been tested for Hirschsprung disease, which is negative. Her gastro ordered a full blood panel and the two results that stand out to me are these:

IgA - 39 (87-474)
Tissue Transglutaminase AB IgA n C - <1

Her vitamin tests are all in the lower range or below normal range. Please tell me what these two results above mean.
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Old 06-16-2015, 01:05 PM   #2
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Welcome chimchimsdad.
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Old 06-17-2015, 06:18 AM   #3
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Default What that means is--

--any celiac tests--anti-transglutaminase or anti-gliadin--that measure the levels of immunoglobulin A for antibodies to gluten will not be accurate, as she apparently has low levels of immunoglobulin A overall (an issue that in itself warrants some investigation; there are people with congenitally low levels of certain immunoglobulin classes, and they sometimes have a bit more trouble fighting pathogens than others).

But bottom line, blood tests for celiac will probably not be accurate for her, and she may need endoscopy with villious biopsy to confirm or rule it out.
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