[GeeFree]

I just found this site and just got my test results back 3 days ago, though I have been gf for almost 7 weeks now. I think this means.... I do not have the Positive Celiac genes but because I carry two copies of HLA-DQB1 0301 and have a very positive anti-gliadin IgA (and this was after 4 weeks gf), I am one of the special ones who are gluten sensitive and should remain gf permanently? Does anyone have any insights into this? Am I interpreting this correctly?

Gluten/Antigenic Food Sensitivity Stool/Gene Panel
Fecal Anti-gliadin IgA 254 Units (Normal Range is less than 10 Units)

Fecal Anti-casein (cow’s milk) IgA 57 Units (Normal Range is less than 10 Units)

Fecal Anti-ovalbumin (chicken egg) IgA 31 Units (Normal Range is less than 10 Units)

Fecal Anti-soy IgA 37 Units (Normal Range is less than 10 Units)

HLA-DQB1 Molecular analysis, Allele 1 0301

HLA-DQB1 Molecular analysis, Allele 2 0301

Serologic equivalent: HLA-DQ 3,3 (Subtype 7,7)

Interpretation of Fecal Anti-gliadin IgA: The level of intestinal anti-gliadin IgA antibody was elevated, indicative of active dietary gluten sensitivity. For optimal health; resolution or improvement of gluten-induced syndromes (mainly falling into six categories abbreviated as NAAAGS – neuropsychiatric, autoimmune, asthma, abdominal, glandular deficiencies/hyperactivity or skin diseases); resolution of symptoms known to be associated with gluten sensitivity (such as abdominal symptoms - pain, cramping, bloating, gas, diarrhea and/or constipation, chronic headaches, chronic sinus congestion, depression, arthritis, chronic skin problems/rashes, fibromyalgia, and/or chronic fatigue); and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well.


Interpretation of Fecal Anti-casein (cow’s milk) IgA: Levels of fecal IgA antibody to food antigens greater than or equal to 10 Units are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. It is recommended that for any elevated fecal antibody level to a highly antigenic food such as milk, that it be removed from your diet.

Interpretation of Fecal Anti-ovalbumin (chicken egg) IgA: Levels of fecal IgA antibody to food antigens greater than or equal to 10 Units are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. It is recommended that for any elevated fecal antibody level to a highly antigenic food such as egg, that it be removed from your diet.

Interpretation of Fecal Anti-soy IgA: Levels of fecal IgA antibody to food antigens greater than or equal to 10 Units are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. It is recommended that for any elevated fecal antibody level to a highly antigenic food such as soy, that it be removed from your diet.

Interpretation Of HLA-DQ Testing: Although you do not possess the main HLA-DQB1 genes predisposing to celiac sprue (HLA-DQB1*0201 or HLA-DQB1*0302), HLA gene analysis reveals that you have two copies of a gene that predisposes to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having two copies of a gluten sensitive gene means that each of your parents and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity may be more severe.

[GeeFree]

• I heard back from the Fine folks at Enterolabs so in case others of you out there are trying to interpret results, thought I would share my clarification.
  
  I was reading this right. I do not have DQB2 or DQB8 which typically are found in those with Celiac Disease. I have 2 copies of DQB1 that make me particularly gluten sensitive-and intolerant enough that I need to remain Gluten free forever. This means I got one gene from each parent and unless they are tested, they do not know if they have a duplicate copy either. However from history, I think I know one does and one doesn't. It also means that each of my daughters has at LEAST 1 copy of the gene, and may have 2 depending upon what they got from Dad. Because of their symptoms, they are going to be tested. I hope this helps if you are looking for help understanding your test.
  
  

Originally Posted by GeeFree

I just found this site and just got my test results back 3 days ago, though I have been gf for almost 7 weeks now. I think this means.... I do not have the Positive Celiac genes but because I carry two copies of HLA-DQB1 0301 and have a very positive anti-gliadin IgA (and this was after 4 weeks gf), I am one of the special ones who are gluten sensitive and should remain gf permanently? Does anyone have any insights into this? Am I interpreting this correctly?

Gluten/Antigenic Food Sensitivity Stool/Gene Panel
Fecal Anti-gliadin IgA 254 Units (Normal Range is less than 10 Units)

Fecal Anti-casein (cow’s milk) IgA 57 Units (Normal Range is less than 10 Units)

Fecal Anti-ovalbumin (chicken egg) IgA 31 Units (Normal Range is less than 10 Units)

Fecal Anti-soy IgA 37 Units (Normal Range is less than 10 Units)

HLA-DQB1 Molecular analysis, Allele 1 0301

HLA-DQB1 Molecular analysis, Allele 2 0301

Serologic equivalent: HLA-DQ 3,3 (Subtype 7,7)

Interpretation of Fecal Anti-gliadin IgA: The level of intestinal anti-gliadin IgA antibody was elevated, indicative of active dietary gluten sensitivity. For optimal health; resolution or improvement of gluten-induced syndromes (mainly falling into six categories abbreviated as NAAAGS – neuropsychiatric, autoimmune, asthma, abdominal, glandular deficiencies/hyperactivity or skin diseases); resolution of symptoms known to be associated with gluten sensitivity (such as abdominal symptoms - pain, cramping, bloating, gas, diarrhea and/or constipation, chronic headaches, chronic sinus congestion, depression, arthritis, chronic skin problems/rashes, fibromyalgia, and/or chronic fatigue); and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well.


Interpretation of Fecal Anti-casein (cow’s milk) IgA: Levels of fecal IgA antibody to food antigens greater than or equal to 10 Units are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. It is recommended that for any elevated fecal antibody level to a highly antigenic food such as milk, that it be removed from your diet.

Interpretation of Fecal Anti-ovalbumin (chicken egg) IgA: Levels of fecal IgA antibody to food antigens greater than or equal to 10 Units are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. It is recommended that for any elevated fecal antibody level to a highly antigenic food such as egg, that it be removed from your diet.

Interpretation of Fecal Anti-soy IgA: Levels of fecal IgA antibody to food antigens greater than or equal to 10 Units are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. It is recommended that for any elevated fecal antibody level to a highly antigenic food such as soy, that it be removed from your diet.

Interpretation Of HLA-DQ Testing: Although you do not possess the main HLA-DQB1 genes predisposing to celiac sprue (HLA-DQB1*0201 or HLA-DQB1*0302), HLA gene analysis reveals that you have two copies of a gene that predisposes to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having two copies of a gluten sensitive gene means that each of your parents and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity may be more severe.