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Celiac/gluten related PN

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Old 09-30-2019, 11:15 AM   #1
P3000g
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Default Celiac/gluten related PN

Hi Folks


I have been suffering from Peripheral Neuropathy for the last 4-5 months. I have gone off allopurinol for my gout (which I suspected initially as the cause) and also taking supplements (R-ALA, ALC, vItamin B12, omega 3) to combat my neuropathy. I did an EMG recently and some bloodwork (copper, zinc, immunoglobulin, protein electrophoresis) which came back normal. I have an MRI scheduled for next month.

I also did a celiac profile test and was normal on immunoglobulin igg and transglutaminase iga but high on deamidated gliadin igg antibodies. Does it mean a conclusive evidence of celiac with normal tranglutaminase but high DGA? Do you think a biopsy is warranted? I started to eat gluten free a couple of days ago, to see if it helps. Any opinions advice is appreciated. Thanks and have a good day..
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Old 10-01-2019, 06:58 AM   #2
glenntaj
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Default It might be--

--though the test with the highest correlation with small intestinal damage and frank celiac is the transglutaminase IgA assay.

The deamidated anti-gluten IgG test is the most sensitive, but least specific, of the tests in a standard celiac panel. There's been a correlated tendency for that test to be the first to go "positive", though, in cases of celiac and especially in cases of non-celiac gluten sensitivity, the latter being an entity that is still somewhat controversial in some circles.
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Old 10-01-2019, 11:13 AM   #3
P3000g
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Default

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Originally Posted by glenntaj View Post
--though the test with the highest correlation with small intestinal damage and frank celiac is the transglutaminase IgA assay.

The deamidated anti-gluten IgG test is the most sensitive, but least specific, of the tests in a standard celiac panel. There's been a correlated tendency for that test to be the first to go "positive", though, in cases of celiac and especially in cases of non-celiac gluten sensitivity, the latter being an entity that is still somewhat controversial in some circles.
Possible that I have non-celiac gluten sensitivity. I dont have the "classic" symptoms of CD.. The only symptom that I have so far is peripheral neuropathy (tingling, pins and needles etc) , besides the positive DGA IGG test .. Trial and error on gluten free for a coupe of months to see if my PN goes away
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