PubMed - 2006

jccgf · 10-25-2006, 06:02 PM

Quote:

Objective. The aetiopathogenesis of psoriasis is still unclear. Associations between gut and skin diseases are well known, since psoriatic patients show a high prevalence of coeliac disease. Small-bowel abnormalities can cause clinical or, more frequently, laboratory alterations that give rise to malabsorption. The aim of the study was to evaluate the prevalence of malabsorption in psoriatic patients. Material and methods. Fifty-five (29 M, 26 F, mean age 51+/-8 years) psoriatic patients in the Dermatology Centre of our hospital and 65 healthy controls (36 M, 29 F, mean age 47+/-9 years) were screened for malabsorption using a D-xylose test. Psoriatic subjects who resulted positive were further investigated in order to reach a better characterization of the malabsorption using serum antigliadin, antiendomysium and anti-transglutaminase antibodies, H2 lactulose breath test, the parasitological faecal test and colonoscopy with retrograde ileoscopy. Results. Altered D-xylose absorption was found in 60% (33/55) of psoriatic patients and in 3% (2/65) of controls. Of the former, 6% had coeliac disease, 21% had bacterial overgrowth, 3% had parasitic infections and 1 patient presented eosinophilic gastroenteritis. Conclusions. Malabsorption was more prevalent among psoriatic patients than among controls. Coeliac disease, bacterial overgrowth, parasitic infestations and eosinophilic gastroenteritis could be possible causes of malabsorption in these patients. Further studies are needed to clarify the pathogenesis and possible causative associations between gut and skin diseases.

Malabsorption in psoriatic patients: Cause or consequence? PMID: 17060119 Nov 2006

jccgf · 10-25-2006, 06:04 PM

CD8-positive T cell-induced liver damage was found in a patient with polymyositis.
Intern Med. 2006;45(18):1059-63. Epub 2006 Oct 16.
PMID: 17043378

Just curious on this one...would love to know if they checked for antigliadin or other antibodiesin this person with RA, liver damage, and polymyositis.

jccgf · 12-06-2006, 08:40 AM

Another from Hadjivassiliou, et al.

Myopathy associated with gluten sensitivity.
PMID: 17143894 Dec 2006

Ataxia and peripheral neuropathy are the most common neurological manifestations of gluten sensitivity. Myopathy is a less common and poorly characterized additional neurological manifestation of gluten sensitivity. We present our experience with 13 patients who presented with symptoms and signs suggestive of a myopathy and in whom investigation led to the diagnosis of gluten sensitivity. Three of these patients had a neuropathy with or without ataxia in addition to the myopathy. The mean age at onset of the myopathic symptoms was 54 years. Ten patients had neurophysiological evidence of myopathy. Inflammatory myopathy was the most common finding on neuropathological examination. One patient had basophilic rimmed vacuoles suggestive of inclusion-body myositis. Six patients received immunosuppressive treatment in addition to starting on a gluten-free diet; five improved and one remained unchanged. Among seven patients not on immunosuppressive treatment, four showed clinical improvement of the myopathy with a gluten-free diet. The improvement was also associated with reduction or normalization of serum creatine kinase level. The myopathy progressed in one patient who refused the gluten-free diet. Myopathy may be another manifestation of gluten sensitivity and is likely to have an immune-mediated pathogenesis. A gluten-free diet may be a useful therapeutic intervention. Muscle Nerve, 2006.
PMID: 17143894

jccgf · 12-07-2006, 06:19 PM

Coeliac disease and primary hyperparathyroidism: an association?
PMID: 17148709 Dec 2006

Quote:

Primary hyperparathyroidism may present with non-specific symptoms, and this may be one reason why patients with coeliac disease fail to improve despite compliance with a gluten-free diet. Seven case reports of primary hyperparathyroidism due to sporadic adenoma occurring in a series of 310 patients with coeliac disease are presented, highlighting the importance of looking for this condition in this population group. A prevalence of primary hyperparathyroidism of 2.3% in this series suggests a significant association between hyperparathyroidism and coeliac disease; most studies have indicated a prevalence of 3 in 1000 in the general population, although one study found that it may be as high as 21 in 1000 in women aged 55-75 years. The average age of patients in our series was 59 years and all but one were women. Further studies are needed to establish a possible association between primary hyperparathyroidism and coeliac disease.
PMID: 17148709

NancyM · 12-07-2006, 10:50 PM

Well what a funny coincidence, I just ran into something else about hyperparathyroidism: http://heartscanblog.blogspot.com/20...acle-drug.html

jccgf · 12-08-2006, 09:37 AM

Thanks for posting that Nancy! I love that these forward thinking doctors are starting to blog! And this one, in Milwaukee

, just 30 minutes away. I will know who to look for next time I need a cardiologist. I need to have my Vitamin D tested. I hate that many doctors think you are nuts to ask for nutritional deficiency testing.

Cara

NancyM · 12-08-2006, 10:55 AM

That's great, Cara! I've been enjoying his blog.

Well, today by another weird coincidence I turned on the TV and it was on the local university's channel and there was a Internist/Professor giving a lecture on hyperparathyroid. And they did mention how taking too much Vitamin D can cause that, in addition to adenomas.

I'd really love to find out how MUCH vitamin D my body needs because I really don't get any sun, I'm photosensitive from the drugs I take and have really pale skin anyway. But I'm also afraid of over-doing it too.

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