I was re-reading this article which says that DQ7 is a celiac gene too, and noticed something that looks to me like DQ1 is a celiac gene too:
http://www.clinchem.org/cgi/content/full/44/8/1755
"Eight of the 122 CD patients lacked both the heterodimer and the DRB104 alleles; therefore, we further screened the DQB1 locus to investigate if other alleles were present in association to CD (2)(14). Two of these eight CD patients showed the DQ2 molecule (DQB10201 allele in heterozygosis); but one of them carried also the DQB10501 allele, also found in Sardinian patients to be associated to CD (15); four showed the DQ7 molecule (DQB10304 or DQB10301 alleles). Another patient carried the DQ8 molecule encoded by the DQB10302 allele, and the remaining patient had the haplotype DQB10501 in homozygosis (15). The DQ8 molecule seems to be an alternative to DQ2 in influencing susceptibility towards CD, being present in up to 20% of celiac patients not bearing of DQ2 in the Mediterranean area (2)(14)(16). Our data do not support an earlier finding that HLA-DQ7 is a nonsusceptible molecule (2). In fact, DQ7 was present in 50% of our CD patients in the absence of the heterodimer and of the DRB104 alleles. Because the DQ7 molecule is very similar to the DQ8 molecule, it could alternatively present similar gluten-derived peptides to restricted T cells (17). DQ7 has been detected in a few CD cases in the absence of DQ2 but in association with the DRB104 alleles (18). "
and they have a reference http://www.ncbi.nlm.nih.gov/sites/en...t=AbstractPlus what is DQA1*0101,DQB1*0501 ?

what do you say?

nora

I found out what 0501 0501 means:
Not DQ1, because that would be 0101 0501 (or 0601 or any 05* or 06*)
there are two alleles that make up each gene and we have two genes. there may be multiple expressions, though, and some expressions are over two genes or somethjing like that.
But there is a good list of what the alleles are on the wiki page about DQ.
http://en.wikipedia.org/wiki/HLA-DQ
and there are good explanations about DQ types and celiac online in some articles in medical publications.
also http://www.ihwg.org/protocols/sbt/voorter-DQB1.pdf
also http://www.tidsskriftet.no/pls/lts/P...SEKS_ID=924350 explains about the alleles and molecules.
These are mainly about DQ2 and 8.
I have some links for DQ9 too:
http://www.ncbi.nlm.nih.gov/sites/en..._uids=10917890 and there is a link to the free article there.

Here I found something on DQA1 *01 BQB1 *05 which is DQ1 or very close:
Db=pubmed&Cmd=ShowDetailView&TermToSearch=12651074 &ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.P ubmed_ResultsPanel.Pubmed_RVDocSum

"HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease
Genetic susceptibility to celiac disease is strongly associated with HLA-DQA1*05-DQB1*02 (DQ2) and HLA-DQA1*03-DQB1*0302 (DQ8). Study of the HLA associations in patients not carrying these heterodimers has been limited by the rarity of such patients. This European collaboration has provided a unique opportunity to study a large series of such patients. From 1008 European coeliacs, 61 were identified who neither carry the DQ2 nor DQ8 heterodimers. Fifty seven of these encoded half of the DQ2 heterodimer. The remaining 4 patients had a variety of clinical presentations. Three of them carried the DQA1*01-DQB*05 haplotype as did 20/61 of those carrying neither DQ2 nor DQ8. This may implicate a role of the DQA1*01-DQB*05 haplotype. None of these four patients carried the DQB1*06 allele that has previously been reported in this sub-group of patients. Of the 16 DQ2 heterodimer negative patients without DRB1*04 or DRB1*07 haplotypes, it was inferred that none encoded the previously implicated DRB4 gene as none had a DRB1*09 haplotype. These results underline the primary importance of HLA-DQ alleles in susceptibility to celiac disease, and the extreme rarity of celiac patients carrying neither the DQ2 or DQ8 heterodimers nor one half of the DQ2 heterodimer alone. Copyright American Society for Histocompatibility and Immunogenetics, 2003

PMID: 12651074
"
just type in the PMID nr and hit enter if the link here does not work

DQB1*06 is DQ1 if the alpha allele is 0101, maybe they mean DQ1 here too:
http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

altogether it looks like that there are celiacs out there who have half of the DQ2 or DQ8 genes but there are those who do not have half the DQ2 or DQ8 gene.
http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum
nora

Hi Nora,
Interesting sites.

I love this chart and will try to paste and see what happens. It really defines the HLA's clearly. It is a chart and may not copy correctly

25 (of 75) Most common DR-DQ haplotypes in Caucasian Americans
http://en.wikipedia.org/wiki/HLA-DQ

Well, I don't know how to shrink the chart because it has 80KB instead of 19KB. If anyone else knows how to do this please upload as it is a good chart to have for everyone's reference.

Llonghair

Yeah. All those questions answered by Dr. Scot Lewey. He has some patients who are celiac but whse genes do not fit, and read those articles about half the genes. He comments about some of the labs only testing for the beta chain, thus missing the alpha chain.
http://www.celiac.com/articles/21567...ing/Page1.html
and several articles on his blog.
He comments specific on Sollid's article.
Now I was tested for my genes at sollid's lab and was negative for DQ2 or 8.
I am quite sure they only tested for the beta chain. I did phone them and as what they tested for but could not get an answer.

Lewey's blog: http://thefooddoc.blogspot.com/2008/...c-disease.html

nora

There are several main opinions on the genes related to the gluten syndrome.

1. Standard celiac speak states that 99% of celiac (subset) patients carry HLA DQ 2 or 8 and these genes predispose thep atient to the gluten syndrome pathways. They specifically refer to villi damage (celiac damage)

2. Ken Fine of Enterolab.com, a research lab, has announced but not published that he finds in his research that HLA 1 and 3 are related to the gluten syndrome (not necessarily the villi damaged subtype). In this region he finds almost no HLA DQ 4 (only 4) genes in patients with the gluten syndrome. All others hve been found to be involved in some of the folks he tests.

3. Dr. Aristo Vojdani or Immunosciences Laboratories believes that the genes are not necessary for some of the gluten syndrome pathways/reactions to occur. However he did not look for the 1 or 3 genes, only 2 and 8. Dr. Vojdani believes toxins (chemical injury), stress and infections can mediate the various gluten syndrome pathways without the genetic predisposition.

This is my first post. I hope I did everything right.

Hope this helps,
Olive Kaiser

hi olive and welcome to neurotalk.

you did just fine posting. if you need any help or have any questions, just send, me a pm.

Not as many as 99%.
Here is one abstract that says they found 61 out of 1008 celiacs who were not DQ2 or 8.
http://www.ncbi.nlm.nih.gov/pubmed/12651074

Other sources say that DQ2 or 8 involved is something like 95% too.
really depends on wether you count in tha half DQ2 genes or not.
And then you have to test for the alpha chains.

nora

Wow !!
Thanks for these great posts.
I have had to read through several times to understand but I am getting there.
Regards,
Rosco.

Now latest news is that they now differtiate and report on which kind of DQ2 and some of the other genes are present. Now they ahve started to report DQ2,2 and DQ2,5 which now means that DQ2,2 is DQB1 0202 (in the beta chain) and DQB1 0201. DQ2,5 should have DQA1 0501 in the alpha chain if they test for it.
Rread the wikipedia charts, and note that there are two charts, the one says which ones are what and the other one gives percentage of how many are prevalent in the population of the top 25 types out of 75 known in caucasians.
So one can have some lesser prevalent combinations and testing only the beta chain will mistype some people.

Enterolab has started to give reports of wether one has DQ2,5 or 2,2 now. This has changed from before.

See this recent posting about the new kinds of report from enterolab.
http://www.glutenfreeforum.com/index...howtopic=46507

nora