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Systemic Autoimmune Disorders in Celiac Disease

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Old 11-26-2006, 06:39 PM   #1
jccgf
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Default Systemic Autoimmune Disorders in Celiac Disease

Thanks to Anne for this find ~

Systemic Autoimmune Disorders in Celiac Disease
http://www.medscape.com/viewarticle/547107
(must register to medscape to read the entire article, but its free)

In part:
Quote:
Purpose of Review: Celiac disease is an immune-mediated disorder clinically characterized by a multitude of symptoms and complications. The comorbidity between celiac disease and other autoimmune disorders has been clearly established.
Recent Findings: Two main theories have been postulated to explain this comorbidity: (1) linkage disequilibrium between the genes responsible for celiac disease and those responsible for the coexpressed autoimmune diseases or (2) untreated celiac disease leading to the onset of other autoimmune diseases. This article reviews the current literature supporting either theory and places the current knowledge in the field within the context of the most recent data on the pathogenesis of celiac disease.
Summary: The current literature did not clearly establish which of the two theories explain the comorbidity between celiac disease and other autoimmune disorders. There is, however, growing evidence that the loss of the intestinal barrier function typical of celiac disease could be responsible of the onset of other autoimmune disease. This concept implies that the autoimmune response can be theoretically stopped and perhaps reversed if the interplay between autoimmune predisposing genes and trigger(s) is prevented or eliminated by a prompt diagnosis and treatment.
Quote:
Conclusion

Based on recent findings concerning celiac disease, the classical paradigm of autoimmune pathogenesis involving specific gene makeup and exposure to environmental triggers has been challenged by the addition of a third element - the loss of intestinal barrier function. Whether the increased comorbidity between celiac disease and other autoimmune disorders is related to increased intestinal permeability causing the passage of environmental triggers responsible for the onset of the autoimmune processes or it is secondary to cosegregation of genes remains to be established.


Here is some additional information about zonulin, which regulates the tight junctions of the intestinal barrier. Zonulin They are doing clinical trials of a new zonulin blocking drug for treatment of both Celiac Disease and Type 1 Diabetes, but it is believed it may be used in other autoimmune disease as well.

Cara
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Last edited by jccgf; 11-26-2006 at 08:42 PM.
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