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Member
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Join Date: Aug 2006
Location: Arkansas
Posts: 239
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Member
Join Date: Aug 2006
Location: Arkansas
Posts: 239
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Good to hear that your son is doing better, Hanna.
Here is another abstract that links h. pylori to iron deficiency anemia. http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract
Quote:
Am J Epidemiol. 2006 Jan 15;163(2):127-34. Epub 2005 Nov 23.
Iron deficiency and Helicobacter pylori infection in the United States.
Cardenas VM, Mulla ZD, Ortiz M, Graham DY.
Division of Epidemiology, University of Texas School of Public Health, El Paso, USA. victor.cardenas@uth.tmc.edu
Using data from the current National Health and Nutrition Examination Survey (1999-2000), the authors assessed whether Helicobacter pylori infection is associated with iron deficiency and iron-deficiency anemia (IDA) in the United States. Iron deficiency was defined as at least two abnormal results out of three biomarkers of iron stores. IDA was defined as a low hemoglobin level in the presence of iron deficiency. H. pylori infection was measured by serology. Complex survey estimators were used in the analysis. For 7,462 survey participants aged >or=3 years, H. pylori infection was associated with decreased serum ferritin levels (percent change = -13.9%, 95% confidence interval (CI): -19.5, -8.0) but not with levels of free erythrocyte protoporphyrin, transferrin saturation, or hemoglobin (percent change = 1.5%, -2.8%, and -1.1%, respectively). Multinomial logistic regression analyses indicated that H. pylori infection was associated with the prevalence of IDA (prevalence odds ratio (POR) = 2.6, 95% CI: 1.5, 4.6) and, to a lesser degree, other types of anemia (POR = 1.3, 95% CI: 1.0, 1.7). H. pylori infection was associated with a 40% increase in the prevalence of iron deficiency (POR = 1.4, 95% CI: 0.9, 2.0) after controlling for relevant covariates. In the United States, H. pylori infection was associated with iron deficiency/IDA regardless of the presence or absence of peptic ulcer disease.
PMID: 16306309 [PubMed - indexed for MEDLINE]
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How is your son's B12 level?
http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract
Quote:
Helicobacter. 2002 Dec;7(6):337-41. Related Articles, Links
Click here to read
Impact of Helicobacter pylori on the development of vitamin B12 deficiency in the absence of gastric atrophy.
Serin E, Gumurdulu Y, Ozer B, Kayaselcuk F, Yilmaz U, Kocak R.
Department of Gastroenterology, Baskent University Faculty of Medicine, Adana Teaching and Medical Research Center, Adana, Turkey.
BACKGROUND: Cobalamin (vitamin B12) deficiency is associated with Helicobacter pylori infection. This study examined how serum vitamin B12 levels relate to gastric mucosa H. pylori density and histology, and to hematological findings in patients with minimal or no gastric atrophy. A second aim was to confirm that H. pylori eradication therapy increases serum B12. MATERIALS AND METHODS: Biopsies of the gastric mucosa from a population of dyspeptic patients were graded for level of chronic inflammation, neutrophil activity, atrophy, and H. pylori density. A total of 145 H. pylori-infected patients with minimal or no atrophy were included in the study. Serum cobalamin level, hemoglobin level, and mean corpuscular volume were measured in the 145 patients before eradication therapy, and in 65 of the subjects after treatment. The hematologic findings before and after eradication therapy and correlations between serum vitamin B12 level and histologic parameters, hematologic findings, and patient age were statistically analyzed. RESULTS: There was no significant correlation between serum cobalamin level and patient age. Before treatment all the histopathological scores were inversely correlated with serum vitamin B12 level (p <.01) on univariate analysis. Only H. pylori density was significantly associated with B12 level on multivariate analysis. Serum hemoglobin and cobalamin levels were significantly increased after treatment, regardless of H. pylori eradication status (p <.001). CONCLUSION: The findings provide strong evidence that H. pylori infection is associated with cobalamin deficiency, and show that this is true even in patients with non-ulcer dyspepsia and minimal or no gastric atrophy.
PMID: 12485119 [PubMed - indexed for MEDLINE]
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09-26-2006, 10:52 AM
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