Amerge (naratriptan) and Maxalt (rizatriptan) are meds in a class called triptans, which are used as abortives in treating migraines & cluster headaches. There are more, but the list is finite, with additions unlikely. As with other medication classes, if one med in the group doesn't work, another med in the same group may work, so "If at first you don't succeed...."

....Another case of trial & error -- taking some time -- in the journey.

Doc

Hey Doc, funny thing is that I tried soooo many migraine meds with no relief (Imitrex, Maxalt, Relpax, Zomig, etc...) Amerge worked the best and I took it for several years, then I had and allergic reaction the last two times I took it

Hmmm. No chance it was something coincidentally concomitant?
How bad was the allergic reaction?

I wonder if one of the others might work for you now...

Doc

Well, my chest got real tight, shortness of breath, a rash, nausea...pretty bad allergic reaction I'd say!

I thought the first reaction might have been a coincidence since I had been taking it so long without issue, but the second time it happened confirmed that it was the Amerge

I have also wondered if the some of the others would help now too...will not try Imitrex again though. The pills and nasal spray did nothing for me and I had a bad reaction to the shots.

I have had the same good experience with Amerge -- every other triptan I have tried makes me feel depressed and only somewhat relieves symptoms, but Amerge (naratriptan) kicks the migraine and makes me feel completely normal. Unfortunately after about 20 years using it, it's not quite as effective as before, but still works in most cases.

Botox was AWFUL -- my head felt bruised for three months and I had a low-level headache all that time as well. The only relief I got was with prednisone. I couldn't wait for it to wear off. And, the doc didn't inject any just above the outside ends of my eyebrows, so when I tried to raise my brows I looked like Jack Nicholson.

And Topamax... blech. Felt awful and didn't help.