On day 35 of the transition from Aimovig to Ajovy. I’m going to try Ajovy for 4 months, then pick what works best.

I have learned the following during my anti-CGRP research on Google and I quote:

Calcitonin gene-related peptide (CGRP) is a vasoactive peptide. It is part of the “inflammatory soup” that is involved in dilation of cerebral and dural blood vessels. Widely distributed throughout the body, CGRP levels in serum increase during migraine or cluster headache. Triptans provide some migraine relief by modulating the CGRP.

CGRP is a neuropeptide that exists in trigeminal ganglia nerves and a potent vasodilator of cerebral blood vessels. CGRP is believed to mediate vasodilatory mechanism of neurogenic inflammation and the transmission of trigeminovascular nociceptive signal from intracranial vessels to central nervous system.

My interpretation and results so far are:

Aimovig and Ajovy work as approved. However, they are complicated drugs.


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