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Old 08-09-2019, 08:54 PM   #21
godfrey19
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On day 35 of the transition from Aimovig to Ajovy. I’m going to try Ajovy for 4 months, then pick what works best.

I have learned the following during my anti-CGRP research on Google and I quote:

Calcitonin gene-related peptide (CGRP) is a vasoactive peptide. It is part of the “inflammatory soup” that is involved in dilation of cerebral and dural blood vessels. Widely distributed throughout the body, CGRP levels in serum increase during migraine or cluster headache. Triptans provide some migraine relief by modulating the CGRP.

CGRP is a neuropeptide that exists in trigeminal ganglia nerves and a potent vasodilator of cerebral blood vessels. CGRP is believed to mediate vasodilatory mechanism of neurogenic inflammation and the transmission of trigeminovascular nociceptive signal from intracranial vessels to central nervous system.

My interpretation and results so far are:

Aimovig and Ajovy work as approved. However, they are complicated drugs.


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Old 08-12-2019, 10:32 PM   #22
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Reporting early! On day 40 started getting headaches and decided to inject Ajovy on day 42. I couldn’t find any research that supported a 60 day detox from one CGRP med to another. Feeling 100% better. But just day 2 in a CGRP world. Will report back.


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Old 08-13-2019, 07:23 AM   #23
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"Triptans provide some migraine relief by modulating the CGRP." I love my Relpax -- my favorite triptan.
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Old 08-24-2019, 12:53 PM   #24
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Been on Ajovy for 14 days. It’s going well. A couple light headaches but minor. Results feel similar to Aimovig 140mg.

I did have a 5 day headache episode while on Aimovig so giving Ajovy a whirl.

Also decided to drop Topamax 50mg as a test. I’ve been on it for 3 years. The Neurologist already knocked it down from 100mg to 50mg. Feel more energetic without the Topamax.

Also after UHC insurance said they wouldn’t cover Ajovy I picked up a new prescription for $245, same price as Aimovig. So who knows what happened.




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Old 10-02-2019, 11:02 PM   #25
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Hello!

Met with my Neurologist today. After 2 shots of Ajovy the headache level is similar to Aimovig 140mg. I have light headaches but no migraines on Ajovy. I also stopped taking Topamax.

Originally when we talked about the CGRP options he was very positive about about the results of his patients. This time he was more guarded and stated that the shots along with a secondary drug is working better. We agreed to meet again and recheck how Ajovy is working as a stand-alone drug.

If the headaches start again he suggested taking 25mg of Topamax twice a day. He also was clear that though the CGRP shots are technically safe, it’s early in the drugs history.

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Old 10-16-2019, 04:22 PM   #26
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How are you, godfrey? Seems like it's time to hear how you are doing.

I need to hear. This is my third day with a fairly stiff headache and my Relpax hasn't helped at all. Makes me wonder about Aimovig or something.
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Old 10-16-2019, 05:37 PM   #27
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Wren,

Sorry to hear about your headaches and Relpax not working as well. I was never prescribed Relpax.

I took another Ajovy shot on 10/10. I’m still off Topamax. At this point I haven’t had a migraine in 2 months. I still get light headaches a couple times a week that can be managed with rubbing Biofreeze gel on the painful spot. I haven’t even had to take standard over the counter headache meds.

Like I mentioned before Amovig 140mg and Ajovy both seem to work. However with the Amovig I did get a couple migraines that were painful. Ajovy, at this point, seems to be holding up a little better for me. My Neurologist said that both are good but results very by person.

We all know the pain and trepidation that goes with migraine sufferers. Good luck on your search!

Godfrey


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Old 10-31-2019, 03:00 PM   #28
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My dermatologist suggested that I try Botox as an add-on to Amovig. This was based on continued minor headaches in my temple areas and above my eyebrows. He also felt that a little Botox above my eyebrows and the lines next to my eyes would help with my appearance.

I decided to give it a try. After one week the Botox has eliminated the temple and eyebrows headaches. Ajovy is still doing its job as well. However, I have experienced some light headache soreness on my forehead where there is no Botox.

Bottom line, I feel that the Botox addition has been a good and my forehead/eye lines diminished.

It’s a little pricey to do both Ajovy and Botox but after 52 years of chronic migraines I’ll pay the price for now.




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