[ashleyk]

Hi, Haven't posted here lately. Possible very effective PD treatment being studied.


may also be efficacious in the treatment of other neurodegenerative proteinopathies, such as Parkinson’s disease
Discovery of a small molecule secreted clusterin enhancer that improves memory in Alzheimer’s disease mice


Discovery of a small molecule secreted clusterin enhancer that improves memory in Alzheimer?s disease mice | npj Drug Discovery


Continued pre-clinical development is warranted for lead candidate DDL-357, which represents a possible new class of therapeutics that might increase the expression of neuroprotective protein networks and could work in tandem with the current AD therapeutics to improve cognition. While further analysis of AD-related biomarkers, off-target effects in the brain, and IND-enabling studies are needed, our drug discovery effort underscores their potential as valuable therapeutic avenue for AD. The findings described here suggest this class of therapeutic, if successfully developed, may also be efficacious in the treatment of other neurodegenerative proteinopathies, such as Parkinson’s disease and amyotrophic lateral sclerosis.