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Old 01-18-2009, 06:34 PM #1
buckwheat
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buckwheat
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Default Prion related diseases

http://emedicine.medscape.com/article/1168941-overview
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Old 01-19-2009, 11:23 AM #2
flounder flounder is offline
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hello there buckwheat,


that link you posted is fairly old ;


Prion-Related Diseases
Thomas Wisniewski, MD, Professor, Departments of Neurology, Pathology and Psychiatry, New York University School of Medicine
Einar M Sigurdsson, PhD, Assistant Professor, Departments of Psychiatry and Pathology, New York University School of Medicine
Contributor Information and Disclosures

Updated: May 1, 2006


end


the infamous sporadic CJD's have increased here in the USA and other places. also, we now have not only atypical h-BSE in the USA, we also have the atypical Nor-98 scrapie in the USA, along with cwd, tme, and BSE documented in an incoming cow from Canada, and of course the home grown cases of BSE in Canada. my point, alot has happened since that old article, and i hope you dont mind if i post a bit of it. ...


CHAPTER 3 Animal Disease Eradication Programs and Control and Certification Programs

snip...

In FY 2007, two field cases, one validation study case, and two RSSS cases were consistent with a variant of the disease known as Nor98 scrapie.1 These five cases originated from flocks in California, Minnesota, Colorado, Wyoming, and Indiana, respectively.

snip...

http://www.aphis.usda.gov/publicatio..._Chapter_3.pdf


NOR-98 Scrapie FY 2008 to date 1

http://www.aphis.usda.gov/animal_hea...crapie_rpt.pps


ATYPICAL TSEs in USA CATTLE AND SHEEP ? (old data)


http://www.bseinquiry.gov.uk/files/sc/seac17/tab03.pdf


Monday, December 1, 2008

When Atypical Scrapie cross species barriers

http://nor-98.blogspot.com/2008/12/w...s-species.html


Sunday, December 28, 2008

MAD COW DISEASE USA DECEMBER 28, 2008 an 8 year review of a failed and flawed policy

http://bse-atypical.blogspot.com/200...28-2008-8.html


November 25, 2008

Update On Feed Enforcement Activities To Limit The Spread Of BSE

http://madcowfeed.blogspot.com/2008/...e-on-feed.html


CHRONIC WASTING DISEASE BLOG

http://chronic-wasting-disease.blogspot.com/

http://stanford.wellsphere.com/heali...ase-2008/13819

0C7.04

North American Cervids Harbor Two Distinct CWD Strains

Authors

Angers, R. Seward, T, Napier, D., Browning, S., Miller, M., Balachandran A., McKenzie, D., Hoover, E., Telling, G. 'University of Kentucky; Colorado Division of Wildlife, Canadian Food Inspection Agency; University Of Wisconsin; Colorado State University.

Content

Despite the increasing geographic distribution and host range of CWD, little is known about the prion strain(s) responsible for distinct outbreaks of the disease. To address this we inoculated CWD-susceptible Tg(CerPrP)1536+/· mice with 29 individual prion samples from various geographic locations in North America. Upon serial passage, intrastudy incubation periods consistently diverged and clustered into two main groups with means around 210 and 290 days, with corresponding differences in neuropathology. Prion strain designations were utilized to distinguish between the two groups: Type I CWD mice succumbed to disease in the 200 day range and displayed a symmetrical pattern of vacuolation and PrPSc deposition, whereas Type II CWD mice succumbed to disease near 300 days and displayed a strikingly different pattern characterized by large local accumulations of florid plaques distributed asymmetrically. Type II CWD bears a striking resemblance to unstable parental scrapie strains such as 87A which give rise to stable, short incubation period strains such as ME7 under certain passage conditions. In agreement, the only groups of CWD-inoculated mice with unwavering incubation periods were those with Type I CWD. Additionally, following endpoint titration of a CWD sample, Type I CWD could be recovered only at the lowest dilution tested (10-1), whereas Type II CWD was detected in mice inoculated with all dilutions resulting in disease. Although strain properties are believed to be encoded in the tertiary structure of the infectious prion protein, we found no biochemical differences between Type I and Type II CWD. Our data confirm the co·existence of two distinct prion strains in CWD-infected cervids and suggest that Type II CWD is the parent strain of Type I CWD.

see page 29, and see other CWD studies ;

http://www.neuroprion.org/resources/...-prion2008.pdf

Sunday, November 23, 2008

PRION October 8th - 10th 2008 Book of Abstracts

http://bse-atypical.blogspot.com/200...8-book-of.html

Saturday, September 06, 2008 Chronic wasting disease in a Wisconsin white-tailed deer farm 79% INFECTION RATE Contents: September 1 2008, Volume 20, Issue 5

snip...see full text ;

http://chronic-wasting-disease.blogs...ssence-of.html

Wednesday, December 17, 2008 White-tailed Deer in Portage County Tests Positive for CWD

http://chronic-wasting-disease.blogs...ge-county.html

Monday, December 22, 2008

CWD DETECTED IN ELK HUNT AREA 117 SOUTH OF SUNDANCE WYOMING

http://chronic-wasting-disease.blogs...117-south.html

Monday, January 05, 2009

CWD, GAME FARMS, BAITING, AND POLITICS

http://chronic-wasting-disease.blogs...-politics.html


Tuesday, January 06, 2009

CWD Update 93 December 29, 2008

http://chronic-wasting-disease.blogs...r-29-2008.html


The statistical incidence of CJD cases in the United States has been revised to reflect that there is one case per 9000 in adults age 55 and older. Eighty-five percent of the cases are sporadic, meaning there is no known cause at present.

http://www.cjdfoundation.org/fact.html

Thursday, November 13, 2008

SIXTEENTH ANNUAL REPORT 2007 CREUTZFELDT-JAKOB DISEASE SURVEILLANCE IN THE UK

http://creutzfeldt-jakob-disease.blo...port-2007.html

Wednesday, August 20, 2008 Bovine Spongiform Encephalopathy Mad Cow Disease typical and atypical strains, was there a cover-up ?

http://bse-atypical.blogspot.com/200...pathy-mad.html

A New Prionopathy OR more of the same old BSe and sporadic CJD

http://creutzfeldt-jakob-disease.blo...e-old-bse.html

Communicated by: Terry S. Singeltary Sr.

[In submitting these data, Terry S. Singeltary Sr. draws attention to the steady increase in the "type unknown" category, which, according to their definition, comprises cases in which vCJD could be excluded. The total of 26 cases for the current year (2007) is disturbing, possibly symptomatic of the circulation of novel agents. Characterization of these agents should be given a high priority. - Mod.CP]

http://pro-med.blogspot.com/2007/11/...e-2007-07.html

http://www.promedmail.org/pls/askus/..._ID:1010,39963

There is a growing number of human CJD cases, and they were presented last week in San Francisco by Luigi Gambatti(?) from his CJD surveillance collection.

He estimates that it may be up to 14 or 15 persons which display selectively SPRPSC and practically no detected RPRPSC proteins.

http://www.fda.gov/ohrms/dockets/ac/...006-4240t1.htm

http://www.fda.gov/ohrms/dockets/ac/...006-4240t1.pdf

USA PRION UNIT BLOG

http://prionunitusaupdate2008.blogspot.com/

Sunday, April 20, 2008 Progress Report from the National Prion Disease Pathology Surveillance Center April 3, 2008

Atypical forms of BSE have emerged which, although rare, appear to be more virulent than the classical BSE that causes vCJD.

see full text ;

http://prionunitusaupdate2008.blogsp...nal-prion.html

CJD TEXAS (cjd clusters)

http://cjdtexas.blogspot.com/

USA WRITTEN CJD QUESTIONNAIRE ???

http://cjdquestionnaire.blogspot.com/

Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518
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Old 04-24-2013, 01:27 PM #3
flounder flounder is offline
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Shocked Tse prion update not good

Wednesday, April 24, 2013

Dissociation between Transmissible Spongiform Encephalopathy (TSE) Infectivity and Proteinase K-Resistant PrPSc Levels in Peripheral Tissue from a Murine Transgenic Model of TSE Disease

http://transmissiblespongiformenceph...smissible.html



kind regards,
terry
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