I have been taking Topamax for migraines and recently underwent a colonoscopy which I have had twice before, this one was very painful and the nurse told me that topamax increases my tolerence to pain medication effectiveness does anyone know if that is accurate? I am now concerned about other proceedures I have to have done and pain meds not working. Thanks. M.

I'm far, far from an expert but I've been taking Topamax since it was released and I've never heard or read that or anything like it.

And I've been through two surgeries and was not told anything like that.

It is widely prescribed for epilepsy seizures (that's why I take it) so maybe you'd like to ask this in the Epilepsy forum too.
Best wishes.

I have never heard of anything like that either. Didnt the Dr. put you to sleep while having the colonoscopy. It wasnt the Topamax

I actually spoke with my rheumotologist today who told me that topamax makes the pain meds metabolize faster and that the Dr. should have compensated for that. He was the one who had referred me for the test. He said his son is on topamax for seizure disorder and they compensate his son's meds when he has a proceedure. M.

what do you mean compenste?

I have been on this drug for 5 years...and finally I have had the common sense to come off...always feared I would put weight on....when I came of..not worth all the other diasters that have happened to my body.

As far as pain meds, I do not know if this is related..however I can not take any PAIN medication while I am on this drug...I get severely ill. Stomache cramps to the point where it is like labour. These are any prescription meds, codine or no codine. I have had surgery, and was treated interveiously, with a pain medication, demeral but since then nothing orally.