Hi , anyone familiar with the off label use of this drug??

Generic drug used to treat acute alcohol or opioid withdrawals?. Evidently there is a connection with low endorphin production and a long list of health problems related to immune dysfunction.

According to the home page the drug used in very low doses, allows the body's own endorphin production to "re-boot" and increases overall immune function. Claiming little to no know side effects.

I looked up a Stanford Hospital trial recently done on Fibromyalgia and have a query in at the Pain clinic there on PN and LDN. Seems promising and if there is validity to this tx then this is the community to know. Thanks for any info.TT

Check out the MS forum. They have lots of discussion on its use and there are people using it so you can get first hand info there.

LDN is a pure opiate antagonist. When metabolised out ogf the body in 4 to 6 hours, it temporarily blockades the mu receptors and the body responds by producing up to 300% ncrease in endorphins. These work to restore immune function, balancing inflammatory responses, cleaning up antiioxidants and promoting immune and repair cell production. This activity is enough to tackle many immune diseases and cancers directly, in the way a healthy body tackles them normally. It will also overome depressions, pain and the fatigue.
Most impoortanht, Naltrexone is safe up to 350mg a day, and at the 50 to 100 mg a day level is routinely prescribed to pregnent mother heroine addicts without risk to the baby, so low doses up to the optimum 4.5mg a day are simply very safe. We at LDNNo0w are campaigning for LDN to be researched properly and used front line as a first do no harm option, because if it works, then the patient can avoifd the risky and expensive alternatives. We do not denigrate these alternatives, because if LDN doesn't work for you, then these are your only options, but I believe people should be offered LDN first so they can at least find out if it helps them. Reports suggest that in most casses it does help, and if you need other methods, it can seriously improve their effectiveness too, requiring less of the 'other' drug too in many cases.
So, I took it because it was safe, and it worked for my SPMS, and now I don't take anything else at all. I also feel that I am no lonhger sick, just disabled, so I can only say that LDN is a fabulous option.

Here's the link to the LDN thread on the MS Forum: http://neurotalk.psychcentral.com/thread71392.html

I've taken LDN for a little over a year and it's been a Godsend for me. It took me a while to titrate up to the 4.5 mg dose but I'm there now and wouldn't be without it. Seriously, I took the standard Interferons that are prescribed for MS but they just made me feel worse than I already did. I finally tried LDN and have never looked back.