I suspect all the U.S. opiate drug manufacturers will do whatever they can to keep this combination of drugs off the U.S. market. I know I wouldn't ever take oxycodone alone or combined with acetaminophn if I could get it in a superior formulation of prolonged release oxycodone with prolonged release naloxone: 12 hours of sustained release v. a bolus 3-4 hr half-life, no perceived loss in analgesia and naloxone's total blockade of oxycodone constipating gut binding. Any ideas of how we can get a better drug combination now? "Not available in the U.S." seems to be the same petty Cold War rationale that blocked the sale of Cuban cigars in the U.S.

Hi Bejart, Welcome.

Why do you suspect that?

Doc