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Old 06-23-2011, 03:25 PM #1
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Thumbs down Patients lose out again to Pharma.....

Quote:
Washington (CNN) -- Two women who say they suffered severe medical complications from a generic drug lost their Supreme Court appeal Thursday, essentially ending their separate lawsuits against pharmaceutical manufacturers.

The justices in a 5-4 ruling said generic drug companies do not share the same level of responsibility as makers of brand-name equivalents, to update their warning labels when significant new risks emerge......
to read more please go to


http://www.cnn.com/2011/HEALTH/06/23...html?hpt=hp_t2
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Old 06-23-2011, 03:37 PM #2
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Tongue

If this link ends, the drug in question is Reglan (metoclopramide), a drug well known to cause Tardive in some patients.

This type of thing gets complex.... I find on the FDA website,
Alaven Pharmaceuticals owns Reglan's trademark.

Alaven no longer exists, and was incorporated into Meda.

So when this suit was initially brought? Maybe Wyeth had it? But not today.
Quote:
Gladys Mensing of Minnesota and Julie Demahy of Louisiana both were prescribed metoclopramide -- marketed as Reglan by Wyeth Pharmaceuticals -- to treat their heartburn and acid reflux. Their pharmacists separately filled the prescription with a generic equivalent made by PLIVA, Inc. and Actavis, Inc.
Wyeth no longer exists either!

I suspect this decision was partisan based, and that is hinted at in the content of the news item, IMO.
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Old 06-23-2011, 03:54 PM #3
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I meant to post this on Medications not Vitamins Forum so have moved it
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Old 06-23-2011, 04:00 PM #4
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Oh, my!

I found it anyway.... my super sniffer internet activity located it without a problem! LOL ( I read "new posts" not the forum index).

I didn't even notice, it ticked me off so much I went to search that patent!

Thanks for posting it Chemar.
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Old 06-23-2011, 05:31 PM #5
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That's just disgusting. I wonder if it's the same in Au..

I found a site that lists all the Trade names and Generic names of Reglan.

Quote:
Generic Names:
Metaclopramide; Metaclopromide; Methochlopramide; Methoclopramide; Metochlopramide; Metoclopramida [INN-Spanish]; Metoclopramide Hcl; Metoclopramide Hydrochloride; Metoclopramidum [INN-Latin]; metoclopramide
Trade Names:
Apo-Metoclop; Cerucal; Clopra; Clopra-Yellow; Clopromate; DEL; Duraclamid; Elieten; Emetid; Emitasol; Emperal; Eucil; Gastrese; Gastro-Timelets; Gastrobid; Gastromax; Gastronerton; Gastrosil; Gastrotablinen; Gastrotem; Imperan; Maxeran; Maxolon; Meclopran; Metamide; Metoclol; Metoclopramide Intensol; Metoclopramide Omega; Metocobil; Metramid; Moriperan; Mygdalon; Neu-Sensamide; Nu-Metoclopramide; Octamide; Parmid; Paspertin; Peraprin; Plasil; Pms-Metoclopramide; Pramidin; Pramiel; Pramin; Primperan; Reclomide; Reglan; Reliveran; Terperan

http://www.pharmgkb.org/do/serve?obj...objId=PA450475
In the article Chemar posted it says...
Quote:
generic drug companies do not share the same level of responsibility as makers of brand-name equivalents
If that's the case then is it only the first list that's made by generic drug companies?

Gosh, lots of different names. Every one of them has the same potential side-effects. Scary
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Old 06-23-2011, 05:43 PM #6
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Unhappy

In the "old days" all liability suits went to the parent company holding the patent. This must have changed here in the US.
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Old 06-23-2011, 10:49 PM #7
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From the article:
Quote:
After four years of taking the drugs, the women each developed tardive dyskinesia, a severe long term neurological disorder that causes involuntary muscle movements.....
I was given this same drug when extremely ill in hospital some years ago, and I suffered the same side effects from this drug as the women in the article.

I remember how distressing those side effects were but they did abate when they changed the medication to something different.

Metaclopromide is still available in Australia as Maxalon.
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Old 06-24-2011, 01:04 AM #8
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I'm glad those symptoms went away for you, Koala.

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p.s.

TSA-USA (Tourette's Syndrome Association-USA) actually gave a grant for the study of this drug as a treatment of Tourette's Syndrome

Quote:
http://www.jaacap.com/article/S0890-...653-1/abstract

The American Academy of Child and Adolescent Psychiatry

Volume 44, Issue 7, Pages 640-646 (July 2005)
A Randomized, Double-Blind, Placebo-Controlled Trial of Metoclopramide for the Treatment of Tourette's Disorder
Rob Nicolson, M.D., Beth Craven-Thuss, M.A., Judy Smith, B. Duncan Mckinlay, Ph.D., F. Xavier Castellanos, M.D.
Accepted 21 February 2005.

<snipped article>

This work was supported by a grant from the Tourette Syndrome Association, Inc.

Disclosure: Dr. Castellanos receives research support from McNeil Consumer & Specialty Pharmaceuticals. The other authors have no financial relationships to disclose.
You can still find Metoclopramide listed on web pages as a potential treatment. Saw one this morning in fact from Seattle area.
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Old 06-24-2011, 02:21 AM #9
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Lightbulb

This drug is quite old.

You know we made liquid dilutions of this drug for newborn infants at the teaching hospital I once worked at. Before Zantac and Prilosec it was used for babies who spit up alot. Imagine what it did to their brains?

Babies born by C-section, do not get their fluids pushed out by delivery, which is nature's way.(babies swallow amniotic fluid) They get lavaged by a tube down the throat. This can injure the esophagus and hence that muscle allows for spitting up more commonly than in vaginally delivered babies. My son had this and it didn't correct until he was about 8 mos old. I lived with it, and didn't complain to doctors, because I knew he would be medicated, and I didn't want that.

Just as adults in our Westernized cultures commonly have GERD, babies can have it too. I personally think this reflects poor EFA status during the pregnancy which puts a huge load on the mother to provide DHA for the developing brain. The GI tract which also needs this critical EFA, then gets lower priority.
This situation may improve some, since there are several prenatals now with DHA added.

Here is a wiki article on it:
http://en.wikipedia.org/wiki/Metoclopramide
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Old 06-24-2011, 04:59 AM #10
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Sorry if I seem a little TS eccentric on this subject, but this is yet another very important reason that we understand in our community that not all tics are Tourette's Syndrome. There are so many other causes of what is termed Tourettism.
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