[melon]

I seem to have a particulair sensitivity to Lidocaine ( no other anaesthetic I am aware of ) that cause my Neuropathy to get considerably worse whenever I have it adminstered - even topically .

Has an one else experinced this with lidocaine , or have any ideas what could be causing it ?


thanks

m

[mrsD]

The anesthetics in the --caine family.... are sodium channel blocking agents. When they wear off, they may cause a rebound of pain, for a brief time. This is most noticeable when used for toothache relief or dental procedures.

The pain that returns often has a throbbing quality and seems worse for a short time. But typically that wears off.

There are neurological problems called channelopathies.

This link has a list of them with sodium included:
http://en.wikipedia.org/wiki/Channelopathy

If you have a genetic error in this process, you most likely would have problems with drugs that affect certain ion channels.
This is pretty difficult to tag by doctors, so may go undiagnosed for a long time or forever in some patients.

[melon]

Originally Posted by mrsD

The anesthetics in the --caine family.... are sodium channel blocking agents. When they wear off, they may cause a rebound of pain, for a brief time. This is most noticeable when used for toothache relief or dental procedures.

The pain that returns often has a throbbing quality and seems worse for a short time. But typically that wears off.

There are neurological problems called channelopathies.

This link has a list of them with sodium included:
http://en.wikipedia.org/wiki/Channelopathy

If you have a genetic error in this process, you most likely would have problems with drugs that affect certain ion channels.
This is pretty difficult to tag by doctors, so may go undiagnosed for a long time or forever in some patients.

hi MissD & Merry xmaz

Just an update on my whole lidocaine issue

While on an HMS / EDS forum ,someone mentioned Lidocaine can cause problems for people with an underlying tendency to have heart rate problems (which I guess includes people with arrhythmias secondary to autonomic problems ) to the extent even topical lidocaine can have cardiotoxic effects in susceptible individuals.

According to reports it mentions suppression of nitric oxide (NO) causes the toxicity of lidocaine to get worse .

see here


And while I havent been brave enough to test that theory out I have noticed that the glyceryl trinitrate ive been using has, had the interesting side effect of helping my EDS / HMS with some success instead.

Admittedly I havent noticed any effects on my neuropathy yet but it does mention it GT as also being used as course of treatment for diabetic diabetic neuropathy here , so perhaps it can helps some others here out after all ?


m

[melon]

BTW In another report I couldnt access it mentions GT being used along with Sildenafil for pn ( no mention of diabetic ) .

Im not sure if that means separately or with it , to have some sort of effect , but a little tempted to almost try it to see.

m

[mrsD]

Yes, nitrates do help dilate things.

But the body tends to become tolerant of that effect with time.
So it may wane and decrease in effectiveness.

[melon]

Originally Posted by mrsD

Yes, nitrates do help dilate things.

But the body tends to become tolerant of that effect with time.
So it may wane and decrease in effectiveness.

strangely enough mine has been consistent since I started using GT back in March - unlike injected supplements which just seem to drop off.

m

[Spiney95]

For what it is worth, I must warm my Lidoderm patches between my hands for several minutes before applying them. Failing to do so causes unbeleivable neuro pain. If properly warmed, I am just fine. Maybe this might help. Best wishes.

[mrsD]

Yes, they are COLD! Whew!

I think it is the adhesive, not the lidocaine. It is an aqueous based gel, and much different from other adhesives we are used to. The moisture in them would be room temperature and feel cold. When they get "old" they are not so cold and also don't stick as well
(not that they stick "well" in the first place ). They can be reactivated, with some misty moisture, like in a steamed up shower sitting on a counter, or a blast of steam from a tea kettle.

If you leave them out in a humid place they will swell up and become very strange looking. I left a used up one on our dock upNorth one morning, it was sort of folded in half with the sticky parts together, and by noon it had swelled up into a gooey mess!
It was overcast and foggy that day.

I find they feel the coldest when applied to my back. And I don't have any numbness there at all.

[Spiney95]

I have had the same problem with topical lidocaine but nothing like the patches. Of course, my body doesn't follow the rules. Merry Christmas.

[melon]

Originally Posted by mrsD

The anesthetics in the --caine family.... are sodium channel blocking agents. When they wear off, they may cause a rebound of pain, for a brief time. This is most noticeable when used for toothache relief or dental procedures.

The pain that returns often has a throbbing quality and seems worse for a short time. But typically that wears off.

There are neurological problems called channelopathies.

This link has a list of them with sodium included:
http://en.wikipedia.org/wiki/Channelopathy

If you have a genetic error in this process, you most likely would have problems with drugs that affect certain ion channels.
This is pretty difficult to tag by doctors, so may go undiagnosed for a long time or forever in some patients.

I am suspecting that is the case and I might I have QT Lengthening ( both my brother and sister suffer from heart issues / mitral valve prolapse )

When I had the lidocaine injected into my ligaments ( via prolotherapy ) I started developing breathing problems then the gastritis pretty soon after, but what I also failed to mention was I had a Demerol IV the first two times before I refused it because it was leaving me with terrible anxiety , confusion . ( I told all this to the nurse too at the time who didnt think it was a big deal )

I never thought much about that till now and I saw this because the symptoms at the time subsided an hour or two after , and they told me is wasnt a big deal. ( though it sure felt it )

Im assuming that alone would of increased this risk of me getting further symptoms from other medications ? ( as I did with the neuropathy from metoclopramide 2 yrs later ) and the lidocaine , dextrose and sarapin injected into my ligaments ?


Also , I have no idea what effect getting injected into ligaments with something like this would have on other areas of my body compared to normal administration because ( as far I know ) there are no reports of any one with LQTS getting prolo / getting worse - and not likely to be given its status

So whose responsible if any potential drug reactions are not noticed before or after being left disabled by something ?

I assume its your own doctor , but if QTLS is as hard to pickup then wont then just make some excuse ?

thanks

m