For over 5 years I have been taking Effexor 75 mg. once a day in the morning. My experience with the drug has shown some efficacy. Four months ago I started taking 0.5 mg. of Mirapex for Restless Leg Syndrome that over the years has become acute. For the past 6 weeks I have been absolutely depression free. Even if I try I am unable to bring myself into that “depression place” that I know so well. I am aware of the challenges and convolutions of neurochemistry and that other factors may be influencing my symptoms. As long as I am symptom free I am happy. Is there anyone working on this drug combination? I thought you might find my experience interesting and if you publish, can you please give me a footnote.