I've been diagnosed with Lupus (SLE) and Sjogren's Syndrome as secondary, as well as being treated for possible diverticulitis.
I now have between 7 to 20 medicines and vitamins I'm told to take daily. I'm having a particularly hard time scheduling all of them according to food intake, and what I can take with other pills, and what needs to be by itself. And on top of all that I'm having difficulty with some the side effects. So please, any help and advice wanted.

Vitamin B-12 timed release from Nature Made (I bought it before I read the vitamin forum and all the good info Mrs. D has listed on the right kind of vitamin B to take.) I haven't purchased the right kind yet, so I'm still taking this, because while it may not be as helpful, I figure it can't hurt... (I've been taking this with the Phentermine on an empty stomach first thing in the morning) Low levels per bloodwork per Neurologist
Vitamin D3 5000 iu from Nature Made one a day. With lunch meal. Deficiency per bloodwork per Neurologist
Vitamin C 60mg VitaMelts from Nature Made one with each meal to help with iron absorbtion. Per hematoligist for anemia.
Phentermine 37.5mg once a day for fatigue and to manage steriod side effects. No side effects from this med. take on empty stomach, first thing in the morning. i usually take the vitamin B12 at the same time. Per rhuematologist.
Doxycycline Hyclate 100mg 1capsule 2x a day for diverticulitis per rhuematologist. This med says take on empty stomach, but has caused weakness and vomiting within an hour of taking it. The pamphlet says it can be taken with food but may make the medicine less effective. Since this is the only way to keep it down, I have been taking it with food usually with breakfast and dinner. (however it has been skipped on my day after the methotrexate day, because I can't fight both at once).
Methylprednisolone 4mg take 3 pills in the morning, it keeps me up if I take them later in the day, causing insomnia. I also take these with food. This is to help with inflammation pain in hands particularly. It works mildly. Hands are functional, but not without pain still, and some days are worse than others. Tried larger do, but no change in effectiveness, so went back to low dose for less risk and at least functionability, per rhumatologist.
Methotrexate 2.5mg 5 pills on Wednesday night on full stomach after dinner. Today is my 4th dose, and medicine has not kicked in yet, and side effects are still bad, and have not waned. I feel fine on Wednesday night, and usually Thursday morning. By lunch time I feel exhausted and weak, like I have the flu. I get hot flashes, and dizziness. I sleep a lot on the day after, the fatigue is bad even taking the phentermine doesn't help. If I'm not sleeping, I don't move much. Letting the dog out to do his business wears me out. I have negative spoons this day. Per rhuematologist to treat autoimmune. (tried plaquinil first, but had allergic reaction, so can not take it ever again, so we moved to this).
Folic acid .4mg 10 pills on Thursdays to counteract the methotrexate. No side effects from folic acid. Per rhuematologist.
Leucovorin Calcium 5mg 2 pills every 6 hours after taking methotrexate to help fight the side effects on Thursdays. Per rhumatologist. This wass recenently prescribed, but doesn't seem very helpful in fighting side effects. I seem to be more alert, but still not physically active.that just means I stay awake through the side effects of the methotrexate. Per rhuematologist.

So my schedule for pills is:
Wake up take B12 & Phentermine.
Wait an hour.
eat breakfast - take Doxycycline
Wait an hour.
Eat something - take methylprednisolone and vitamin D.
Several hours go by.
Eat supper - take doxycycline
(Exception:
Wednesdays - skip evening doxycycline and take methotrexate.
Thursdays - add in Leucovorin Calcium every 6 hours, and add folic acid 10 pills with lunch. On Thursdays I also skip morning dose of doxycycline, and possibly skip evening does as well if I don't feel well from the methotrexate.)

Is there a better way to do this? Am I taking these in an okay order for effectiveness? Are there other things I can do to lessen the downtime from the methotrexate, and feel better? As it stands I can't plan anything on Thursdays, and even Fridays.