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Old 07-04-2014, 06:11 AM #11
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Naturemade products are fine.

You can swallow the B12. Chew them up if they are flavored and follow with water. (you end up swallowing sublinguals anyway and your saliva contains the B12).

Presence of food however, impairs absorption.

I don't recall seeing studies on divided doses vs one large dose however. But logic tells me a larger dose will possibly be better, because there is more available for passive absorption, which is a physical process. However, the transcobalamin in the intestine may only be available in small amounts. That has not been fully researched yet.

Most of our members here report very high blood levels of B12 in testing using 5mg once a day on an empty stomach. So this is easy and does work...I just wouldn't complicate matters at this time with multiple doses which is confusing to many people and ends up with poor compliance as a result.
I think it is more important to take the B12 everyday, however, at this point. Skipping days will lower the concentration in the blood, and lower levels do not penetrate the CSF well where it is really needed. (CSF = cerebrospinal fluid)
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Old 07-07-2014, 10:14 AM #12
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Originally Posted by mrsD View Post
I think the folic acid is okay, as long as you use B12 with it.
There is some controversy about folic acid vs methylfolate now.
The theory is that folic acid may compete with the methylfolate at the blood brain barrier. So the B-right has methylfolate in it, and if you give extra, it might be best to stick to that form.
Folic acid is not active in the body and has to be activated to the methyl form.

The timing is not so important. The oils go best with food, and the B12 should be done on an empty stomach. Those are the only major issues to watch for.

Carlson's is good. We used it for our son for his ADHD supplementation.

I have found that taking my Krill oil at night, seems to work better for me than in the daytime. I seem to sleep better and have more dreaming. So taking some of the fish oil at night may work the same way. Krill does not reflux but the fish oil might, so taking it at supper and remaining upright after dinner is best.
Hi mrsD. Have some followup questions thank you!
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Old 07-07-2014, 10:33 AM #13
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Naturemade products are fine.

You can swallow the B12. Chew them up if they are flavored and follow with water. (you end up swallowing sublinguals anyway and your saliva contains the B12).

Presence of food however, impairs absorption.

I don't recall seeing studies on divided doses vs one large dose however. But logic tells me a larger dose will possibly be better, because there is more available for passive absorption, which is a physical process. However, the transcobalamin in the intestine may only be available in small amounts. That has not been fully researched yet.

Most of our members here report very high blood levels of B12 in testing using 5mg once a day on an empty stomach. So this is easy and does work...I just wouldn't complicate matters at this time with multiple doses which is confusing to many people and ends up with poor compliance as a result.
I think it is more important to take the B12 everyday, however, at this point. Skipping days will lower the concentration in the blood, and lower levels do not penetrate the CSF well where it is really needed. (CSF = cerebrospinal fluid)
Would you recommend taking Potassium also? I have read that taking B12 will result to lower levels of Potassium?

Thank you!
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Old 07-07-2014, 11:37 AM #14
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The only mechanism of potassium lowering comes from people who are severely anemic. The introduction of B12 to these patients results in rapid red cell formation in the bone marrow and these cells grab lots of potassium.

In others with normal red cell counts, it is not likely that potassium levels will be affected.

Potassium OTC is regulated by the FDA at 99mg a tablet. Most food sources are far higher than that. So getting potassium from food, is best. A can of V8 is about 800mg by comparison.

If you suspect low potassium it is best to get that tested by a doctor to see if it is really low and by how much...then figuring out whether a RX for potassium is needed and having the doctor prescribe the correct dose.

Type into Google.... "potassium content of foods"... potassium is pretty commonly available and only if a person has chronic diarrhea or is taking a diuretic does it become low.

The new daily suggested intake from food is 4,500 mg a day.
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