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Old 09-15-2014, 01:00 PM #1
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Default Duloxetine ????

Hi Everyone, Have taken along time to get off Lyrica after severe reactions. Doc now suggesting Duloxetine. Whats this all about ? Is it safe ? My Neuropathic pain has returned with muscle spasms around face and neck.


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Old 09-15-2014, 05:55 PM #2
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Duloxetine (Cymbalta) is an SNRI antidepressant. Like Lyrica, it has helped—and is helping—a great many people, however also like Lyrica, some people are finding it very difficult to get off of (among other issues). I'm not suggesting this would/will happen to you, but I think considering your experience, it's something you should be aware of.

Here is one report about Duloxetine Discontinuation Syndrome isued by the American FDA.

duloxetine

snri

serotonin syndrome

duloxetine discontinuation syndrome

Doc
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Last edited by Dr. Smith; 09-16-2014 at 12:27 AM. Reason: correction
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Old 09-15-2014, 05:58 PM #3
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Quote:
Originally Posted by Dr. Smith View Post
Duloxetine (Cymbalta) is an SSRI antidepressant. Like Lyrica, it has helped—and is helping—a great many people, however also like Lyrica, some people are finding it very difficult to get off of (among other issues). I'm not suggesting this would/will happen to you, but I think considering your experience, it's something you should be aware of.

Here is one report about Duloxetine Discontinuation Syndrome isued by the American FDA.

duloxetine

ssri

serotonin syndrome

duloxetine discontinuation syndrome

Doc
snri. they just took me off it and put me on Zoloft but it was very effective for a number of years
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Old 09-16-2014, 12:53 AM #4
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Quote:
Originally Posted by markneil1212 View Post
snri.
That's correct; Thank you. (I corrected my previous reply)
Aside from that, everything else still holds.

Quote:
they just took me off it and put me on Zoloft but it was very effective for a number of years
??? ...Just took you off what, the Lyrica or duloxetine? Zoloft/sertraline IS an SSRI; same admonishments/concerns as above.

Are they putting you on sertraline or duloxetine for depression, pain, Lyrica withdrawal or what?

Doc
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Old 09-17-2014, 02:32 PM #5
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Default Dr Smith duloxetine

Quote:
Originally Posted by Dr. Smith View Post
Duloxetine (Cymbalta) is an SNRI antidepressant. Like Lyrica, it has helped—and is helping—a great many people, however also like Lyrica, some people are finding it very difficult to get off of (among other issues). I'm not suggesting this would/will happen to you, but I think considering your experience, it's something you should be aware of.

Here is one report about Duloxetine Discontinuation Syndrome isued by the American FDA.

duloxetine

snri

serotonin syndrome

duloxetine discontinuation syndrome

Doc

Hi Doc , Thanks. You express my concerns exactly. Been to Homeopath . Have you used them ? A number of suggestions being made including pregabalin in homeopathic potency . Have you heard of this. I feel as though my system is very hypersensitive after what I've been though so far and aI am very cautious. Own Doc basically taking attitude now of leaving all decisions to me after the carry on with the Lyrica. They seem a bit scared after me last reactions.

Thanks

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Old 09-17-2014, 02:34 PM #6
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Default Duloxetine markneil

Quote:
Originally Posted by markneil1212 View Post
snri. they just took me off it and put me on Zoloft but it was very effective for a number of years
HI there, did not know that this was an SSRI. Once took this years ago and was VERY ill.

Just seen other post saying SNRI . Isthis like an SSRI ?

THanks


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Old 09-17-2014, 02:50 PM #7
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Difference between SNRI and SSRI

The SSRIs affect serotonin selectively and the SNRIs work a little differently and no so selective.

from Mayo Clinic - scroll down each webpage to section to

How SNRIs work

How SSRIs work
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Old 09-18-2014, 09:31 AM #8
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Quote:
Originally Posted by Johnsonsyard View Post
Hi Doc , Thanks. You express my concerns exactly. Been to Homeopath . Have you used them ? A number of suggestions being made including pregabalin in homeopathic potency . Have you heard of this. I feel as though my system is very hypersensitive after what I've been though so far and aI am very cautious. Own Doc basically taking attitude now of leaving all decisions to me after the carry on with the Lyrica. They seem a bit scared after me last reactions.

Thanks

Nick
Nick,
I don't buy into the whole concept; IMO, homeopathy is quackery.

OTOH, if the doctors who say that, 'Lyrica withdrawal/discontinuation syndrome is all in a patient's mind' are correct, then homeopathy—which is also all in the patient's mind—may be a valid treatment/cure. If so, it could validate those doctors' claims/positions for those patients.

Doc
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Old 09-18-2014, 02:49 PM #9
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I know people who use homeopathy for various different ailments and they find it helpful.
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Old 09-18-2014, 11:24 PM #10
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Quackwatch...
I read on his site long ago, but made my own decisions after actually studying & trying various therapies etc. that he pooh poohed... and they worked and helped for me.

I will say that much depends on the practitioner, communication, and follow thru.
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