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Old 05-02-2021, 06:55 AM #1
user123 user123 is offline
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Default Baclofen induced prolongued chemical imbalance / no medications working

Hello all

I will jump right to the point. I had misussed Baclofen, around 3 years ago, had a come down, and from that time on, some things have changed. F.e.:

- even small dose of alcohol or baclofen caused a though-process rush, like even after one beer I was feeling like **** for 2 days from then on - a state which I could describe to being simillar to benzodiazepines withdrawl. I was being unable to make simplest decisions when being in this state like buying a candy bar - a feeling like there were to much information and factors going into my consiousness. (I don't drink for over 2 years now.)

- when I was in that above mentioned "thought-process" rush, also other substances which usually worked on me didn't work at all or totally different. F.e. Carbamazepine which normally used to put me to sleep with 12.5 mg, when in that state didn't do literally anything even in the dose of 50mg (and I had zero tolerance for it at that time). Also stimulating drugs didn't work at all then.

I would normally not pay that much attention to it since I am trying to live sober now, and I don't miss alcohol that much, but I have some reasons to think that even though I'm not in this "total-thought-rush" process, at the moment my mental state has changed anyway on the day-to-day basis.

I have substance missuse history with other substances as well - dissociatives, stimulants, benzodiazepines, psychodelics (almost 3 years sober now from everything), and it was sometimes hard for me to tell which ones are causing what in my current mental state, but one thing I know for sure - during the whole period of substance abuse, I have never experienced anything near close to that drastic change that I saw after Baclofen misuse. (I haven't even use that much of it, roughly 1 package, compared to tenths of packages of benzodiazepines which I used in the past which did nothing compared to this).

Many psychiatric drugs (prescribed by professionals and under their supervission), that have previously worked on me now don't work even in this sobriety period I have: - venlafaxine, - mirtazapine - pregabaline. (last tested about 2 years ago, but did close to nothing)

I am not that much concerned of the medications that don't work, since I don't take anything now, (I pointed this out just to give the bigger picture of the situation). But my concern is that this is a sign of some brain neurochemical/receptor altered state and much of it may be the root cause of my every-day problems. I think my personality also change a bit, for sure some of it was due to all of the substancese misuse and addiction, but nowadays I am starting to think that most of it might be caused because of that imbalance I got from that single and sad baclofen "adventure".

Not that rarely a single word in a conversation is causing me to totally drift off with my thought process, and start "thinking about how I'm thinking". Also the decisions are still much more difficult for me to make, like I take some abstract factors into account, or make a some unrelated connections between things which is causing like an "information-overload" in my head. Very often this is related to very simple decisions like whether to double check if I checked my car's doors. Also sometimes it feels like I anylyze my behaviour constantly even smallest of things, analyze my thought process, analyze my intentions. I sometimes check house doors after closing like 5 times, which didn't happen to me before. Also I have that excesively consious connotations in my head sometimes that are simillar but not that strong to those one in the period of Baclofen come-down.

All of this basically brings me to think that I haven't fully recovered since then, and there is something with my brain physically not only psychologically. I would value some hints from you on the subject like what could I do in this case, and how to approch this subject.

Unfortunatelly the doctors I have worked with up to this point (psychiatrists) didn't help much, and didn't seem at all to know that much on the subject of the receptors. I will be grateful to hear from you on the subject, and how possibly can I approch this, and what I can do.

Is it possible that my GABA receptors or Glutamate receptors were somehow deregulated? How to repair them?
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Old 05-02-2021, 03:07 PM #2
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TLDR:

Baclofen mixed with alcohol induced what I think might be long lasting changes in my brain functioning, which last now for around 3 years despite being sober from all drugs.

Psychological symptoms: decision-making trouble, over-analyzing, being rather uneasy, OCD-like behavior, something which I would describe even like a personality change at this point.
Neurological symptoms: many drugs which worked on me didn't work after that incident (like they used to, or at all): - mirtazapine, - pregabaline - wenlafaxine

What can be the cause of this? Deregulated GABA / glutamate receptors? How can I check to be sure what exactly is happening now, what happened then and how to potentially heal after this? Is this possible to regulate GABA / glutamate receptors after this back to normal? Any medications or medical examinations that could come in handy here?

Kind regards for any replies
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Old 05-02-2021, 11:55 PM #3
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Hi user123

Welcome to NeuroTalk .

Have you seen a medical doctor about this?

Best wishes.
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Old 05-03-2021, 06:16 AM #4
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Hi, I am not even sure what kind of doctor to visit. My experience with psychiatrists is that they usually don't know that much about receptors, and I usually didn't get much help or understanding from them when I tried to explain this.

I thought about visiting neurologist or some kind of psychiatrists but on a professor level. What do you think?

I would also probably need to back this up with some theory, as I think like it is a pretty rare condition, as even on another forum dedicated to this kind of stuff I have hardly received any feedback after posting on the subject.

TBH I also write here assuming that there might be someone with the knowlege appropriate to at least point me to some reasearch that could come in handy when talking to a doctor. From my experience it is often worth doing some reasearch beforehand and then consult it with a professional...

Kind regards
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