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Does anyone on Copaxone suffer from Insomnia ?

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Old 02-23-2008, 08:22 PM #11
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Lightbulb The active ingredient...
in Tylenol PM is the PM part= Benadryl (diphenhydramine).

You can buy this separately and not worry about overdoing the Tylenol part.
It is very inexpensive.

3 x 25mg Benadryl is what is in 3 Tylenol PM's.

People with MS might want to try methyl B12... I just put a quote up on PN about this:
Quote:
The most well studied use of methylcobalamin has to do with sleep. Although the exact mechanism of action is not yet clear, it is possible that methylcobalamin is needed for the synthesis of melatonin. Available information indicates that methylcobalamin can modulate melatonin secretion, enhance light-sensitivity, and normalize circadian rhythm (your 24-hour clock). Because of this, individuals supplementing this form of B12 often have improved quality of sleep, often will require slightly less sleep, and will not uncommonly report that they feel a bit more refreshed when waking in the morning. Methylcobalamin is particularly effective when your 24-hour clock is not running smoothly. This may be indicated by a need for excessive sleep, changing sleep-wake cycles, or a tendency to have altered sleep wake patterns. As examples, you might require 10-12 hours of sleep, or you might not feel tired until 2-3 am and you might wake at noon, or you might find that you wake a bit later every day and go to be a bit later every night. Under all of these circumstances the combination of methylcobalamin (about 3000 mcg daily) and exposure to bright light in the morning can help reestablish your 24-hour clock.
from http://www.dadamo.com/napharm/store3/template2/b12.htm

There are papers on PubMed using high dose B12 in MS patients, in Japan.
http://grande.nal.usda.gov/ibids/ind...s&therow=92122
This is an older paper, and I don't suggest anyone here use 60mg daily...
but B12 does come up in MS treatments occasionally and is very effective for some. The Methyl version is the one to get, not the traditional cyano.
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Old 03-01-2008, 01:58 PM #12
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I've been blaming Copaxone but now I'm not so sure I looked up side effects of Baclofen which I take and Dry mouth which I have and sleep problems surprisingly insomnia so maybe this is the culprit as to why I'm not getting sleepy at night.
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Old 03-14-2008, 10:55 AM #13
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Since this thread was started, I switched to doing my copax shot in the morning. A) more likely to do it. B) see if it made a difference.

Still takes me awhile to fall asleep at night, but noticed it's been a deeper sleep than it was before. So switching when I injected worked for me.

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