I've been Copaxone for 3 months and for the last several days,I'm not sleepy at night at all I'm wide awake and I can't figure it out. I've had to resort to taking Tylenol PM at night just to get a good night's sleep I don't want to get addicted to the drug and then feel like I can't go to sleep without it. I also take baclofen but only a small dose 10 mgs at bedtime. Maybe it's stress I don't know I did read the copaxone brochure that comes with my medicine when it's delevered and it say in 2 percent of patients it talks about insomnia and or sleep disorders.And copaxone also causes dry month too,I went to the dentist last week for a check-up and it's not good.I have early peridontal disease at my last check-up most of my teeeth were 2's and now I have 4's and one tooth is a 5 and I need about 6 teeth deep cleaned they have to numb me up and they clean under the gums or something like and it costs alot of money and I have No dental insurance. The hygentist said alot of people with auto-immune diseases suffer from alot of dental problems. I guess it could be stress as I am stressed out about all this. Thanks for listening Kristi.

Do you take your shot at night? Maybe changing it to morning would help.

I've read elsewhere that it has caused sleep problems for some people. I take other meds that disrupt my sleep pattern, so I take 0.5 mg of Ativan at bedtime. I've been doing that for years.

Hope you work it out.

react to amino acids this way. It depends on your metabolic status.
Everyone has different ratios of aminos in their systems.

Glutamic acid is a neurostimulant, and may be the culprit.
One remedy for reactions to glutamate in foods, is to use vitamin B6 to offset
reactions.

You might try using a P5P product-- activated B6 and see if that helps.
NOW makes one: One a day of this is plenty.
http://www.iherb.com/ProductDetails.aspx?c=1&pid=740

Stores that have a large NOW section may have it.. but it is reasonable online at iherb.

I do not know enough about MS and vitamins however, to suggest that B6 is helpful or interferes with other MS treatments. So keep that in mind. If you can use B-complex okay, then try that or the more active P5P.

Thanks Miz Barbie, I have though about taking my shots in the morning instead of at night I may try it and see how I feel.


Thanks mrsd, what you said sounds very interesting indeed.

Thanks again Kristi.

Kristi

When I was on Copaxone, I took my shot in the morning. I didn't need any more sleep interruptions than I already had. When I first started it, I took my shot at night and had trouble sleeping. I just figured it was the C so changed the shot to morning right after my shower.

I also didn't use the autoinflictor which cut down the site reactions but in the end, I had to quit C because of the severe fatigue that I was experiencing.

Hi,Av8rgirl

I have a question for you so how long were you on Copaxone before your sleep was interrupted see I 've been on C for almost 4 months now and this sleep issue justed started for me about 2 weeks ago out of the blue,I think I'm going to switch to morning shots and try it. See with me I'm not getting tired at night like I should be maybe it's the C or maybe stress heck I dunno. Thanks moderator

Honestly, I had the exact opposite reaction. I didn't realize the Copaxone had anything to do with it until I quit. It wasn't the sole cause of my fatigue, but it has improved somewhat since I no longer take it..If it kept me awake, I'd probably still be taking it, whether it helped slow down MS or not..

This morning I did my first morning shot were see what happening I'll give this a month I'll see how I feel at night if there's no change at night within a month and I'm still not getting tired at night then it's probably not the Copaxone and it's something else.

I've been on Copaxone for over 3 years now. I do my shots at night and don't have any sleep problems, knock wood!

Good luck figuring it out.

Wow...It's funny to be reading this thread. I've been taking Copaxone for about two years (?) and I've been dealing with pretty severe fatigue for the last six months or so.

This time, I'm pretty sure the fatigue has more to due with my nighttime sleep quality than anything else. I've tried switching my copaxone from nite to morning, and even stopped taking the shot for a short time...made no difference.

It gets to the point that I'm so exhausted, but in order to get a good nite's sleep, I have to take about three Tylenol PMs. Of course, the next day I feel slightly hung over...but at least I don't feel tired

It doesn't make sense to be so tired but still not be able to sleep through the night without taking a drug. The weird thing is, I have experimented with smaller doses of Tylenol PM and if I don't take three tablets, I don't sleep through the night. That's more than the dose they recommend, so it's not something I feel I can take often.

I guess it's time to go visit the neuro.