((Mickey)) you're welcome.

Though, it took awhile in the beginning to figure out what worked for me. We tried taking the preventive med route, but that didn't work. Only abortive meds worked, and Imitrex nasal spray was the one that worked for me. I tried the pills, but they made me too sick to my stomach and take too long to work. The Imitrex spray sure tastes nasty going down the throat (if you sniff it in too hard!), but it's worth the relief.

Tylenol, ibuprofen...they don't work for my headaches. It's gotta be either the aspirin or Imitrex.

A serial killer from the 70's!? LOL

Best wishes for something that really works for you!

we will see this device replace drugs... that is if the drug industry does not block it or assassinate the inventor:

http://www.scientificblogging.com/ne...away_migraines

I heard that 6mos was the expected release time!
We'll see.

Hi all,
Most would agree with a non invasive approach and the TMS sounds good but they originally researched and trialed it for Parkinson's and other medical problems many years ago. There was a lot of debate and conflicting findings, you know how it goes?
Unless there is overwhelming +results it will fizzle out. I like many could benefit but as Mrsd said if it's not blocked or the price is excessive.

Mickeybee - Not many doctors recognise toxic signs, easier to pass it off as anxiety or another disorder. An elderly woman here was on lithium, prescibed a medication by her optometrist. As she was old several doctors suspected parkinson's. Routine visit to her GP required blood/lithium check, levels were elevated due to an interaction, she has Tardive dyskinesia.
Nick

Could you please elaborate on this? Which eye drop did the optometrist give?

I rarely see elderly patients on lithium. It was rare in the long term care facility. Renal function in the elderly is usually impaired to some extent making lithium hazardous to use.

Also lithium is not a common cause of Tardive. In fact, it has been used to REDUCE tardive in patients who have it:
http://linkinghub.elsevier.com/retri...24977X07001496

It is possible this elderly patient had a dystonia of some sort. But without a full examination of her med list it would be hard to say.

Cholinergic drugs like pilocarpine are not used much anymore for glaucoma. They do cause dystonias in some patients, especially in the higher dose range.

If you know more about this patient I'd like to see that data.

Hi again,
I typed a full reply earlier but it all fell through and couldn't post it so I give a short note for now.
The meds were timolol inhibace plus and lithium. Conclusion after the investigation was that timolol eye drops led to early adverse effects and a doctor prescribed the inhibace pus for suspected hypertension. Combined effect of the beta-blockers with lithium caused decreased renal clearance hence the rise in lithium levels to a toxic state.
It was admitted that signs of lithium toxicity were present, some doctors thought Parkinson's as the woman was elderly. Doctor's didn't check lithium levels even though literature gives clear warnings regarding beta-blocker therapy and lithium/toxicity.
Agreed, as you've said lithium would rarely cause tardive disorders within the therapeutic range.
Possibly you would agree, an elderly woman would be safer on an alternative type of medication.
for now

I've been looking around about this, because I have never seen an elderly person on lithium in the first place. Renal clearance issues typically preclude that drug.

I ran Timolol eye drops and timolol tablets thru a drug checker:
The eye drops contribute much less drug to the body than tablets would and therefore have no interaction listed either:
However, beta blockers do slow down the heart and therefore, reduce blood pressure. (this is called bradycardia)
from http://www.medicinenet.com/lithium/page2.htm

I did find a potential explanation for the other drug listed for this patient:
Inhibace plus is a combination ACE inhibitor (not available in US) and hydrochlorothiazide.
Not only does the ACE inhibitor family affect lithium, the diuretic hydrochlorothiazide is serious for patients on lithium!
http://books.google.com/books?id=F0n...sult#PPA803,M1

It appears to me that there is more than one serious issue here for this patient. She should NOT be on lithium in the first place if she has hypertension, and/or reduced renal clearance.
The timolol eye drops are a much smaller if any contribution than the Inhibace Plus, from what I can see in the literature!

Thanks for the post, it is a very interesting interaction!

Dude being on lithium you should know that you CANNOT HAVE NSAID's at all. Ibuprofen is a no no no the only thing you can have for pain is Tylenol. Be careful with all that.. Do your research.. Cause it can cause some pretty bad affects like Lithium Toxicity

Thank you for the reminder. I see the link I used above for this issue has closed. Here is a new one:

http://www.drugs.com/interactions-ch...=1310-0,1477-0

From the "moderate" classification for this interaction, it appears that individual renal handling of both drugs determines the potential for negative reactions. Anyone on lithium should be getting periodic monitoring anyway. Some people just cannot handle lithium well because of their own renal status.

Lithium remains a difficult drug for some people to tolerate.

Hi All,

Just fyi there is a study which you can find if you Google "hydrocodone" and "bipolar disorder" which links opiates -- and hydrocodone especially -- to manic/hypomanic episodes in those with bipolar disorder. A negligent doctor prescribed me hydrocodone after an outpatient procedure even though I had listed bipolar disorder as a condition I had. Over the next few weeks my life went totally haywire after 2+ years of stability.

In my opinion a bipolar person should never take hydrocodone.

--- Just wondering what outpatient procedure you had that this medicine was prescribed and what the dosage was? Also, do you take meds for the bipolar disorder and did this doctor know this???Hope that you are doing better now.