Medications & Treatments For discussion about medications and treatments for any disease or health condition, including issues of medication toxicity.


advertisement
Reply
 
Thread Tools Display Modes
Old 11-27-2006, 06:26 PM #1
Dolfinz's Avatar
Dolfinz Dolfinz is offline
Member
 
Join Date: Oct 2006
Location: Mass
Posts: 241
15 yr Member
Dolfinz Dolfinz is offline
Member
Dolfinz's Avatar
 
Join Date: Oct 2006
Location: Mass
Posts: 241
15 yr Member
Smile Piroxicam

Hi there !
I thought I would ask if anyone is using this med. I have Aterial TOS and this is a med they put me on in case I get a bad flare up but I was told not to stay on it daily. Has anyone had any experience ?
Dolfinz is offline   Reply With QuoteReply With Quote

advertisement
Old 11-28-2006, 06:59 AM #2
mrsD's Avatar
mrsD mrsD is offline
Wisest Elder Ever
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Post piroxicam is not a popular NSAID drug...

A cloud of suspicion hangs over it even today.

http://findarticles.com/p/articles/m...v20/ai_4473536

It is hardly used anymore.

I suggest you discuss this with your doctor. Why this particular NSAID?

http://rheumatology.oxfordjournals.o.../full/40/6/603
Quote:
Sudoxicam was the first oxicam introduced to clinical research. It has documented disease-modifying effects in rheumatoid disease, as has benoxyprofen [6]. But sudoxicam was withdrawn after its idiosyncratic hepatonecrotic potential was noted (rarely), and a number of related deaths ended all clinical testing.

Piroxicam, an analogue of sudoxicam, succeeded it. This approved NSAID was to lead to more deaths from gastrointestinal bleeding than had been documented with any other NSAID to date [7].
There were attempts at one time to take this off the market. Pfizer has
blocked those aggressively.

This is the drug info from Pfizer... http://www.pfizer.com/pfizer/download/uspi_feldene.pdf
In it are stats stating that continuous use for 8-12 weeks is necessary for therapeutic effect. So taking this intermittently exposes you to GI bleeding risk without therapeutic effect.

To date, naproxen is the only NSAID that has marginally passed the cardiovascular risk studies for NSAIDs. It too can cause GI issues, but they are less frequent than piroxicam.

GI bleeding risk has been found to vary from person to person.
This article reveals increased risk in those with autoimmune disorders:
http://mednews.stanford.edu/releases...singh1198.html

If you take SSRIs for depression, risk is higher also.
http://www.drug-injury.com/druginjur...ing/index.html

Some studies show use of a proton pump inhibitor like Prilosec may reduce
risk of GI bleeding, so some doctors give them with NSAIDs.
This article is interesting, informative and suggests interventions and explains risk factors for GI bleeding:
http://www.uspharmacist.com/index.as...51/default.htm
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei

************************************

.
Weezie looking at petunias 8.25.2017


****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.

Last edited by mrsD; 11-28-2006 at 03:12 PM. Reason: adding link:
mrsD is offline   Reply With QuoteReply With Quote
Reply


Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off



All times are GMT -5. The time now is 08:29 PM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.