DX with MS in 1999 after 10 years of issues. Dx with Lyme in 2004.

From 1999 to 2008 I took Sinemet for my restless uncoordinated legs, between 2 - 8 tabs of 25/100 per day. Mostly around 4 tabs. As predicted by the prescribing neuro, it lost effectiveness after 9 years.

I switched to Mirapex from Sinemet in March 2008. Started having more problems walking in July 2008. Finally weaned myself completely off Mirapex in January 2009 after reading Once Upon A Pill about the horrors of Sinemet and dopamine supplementation. Weaning took about 4-5 months.

I now take Baclofen or Zanaflex for the legs.

My legs are still very stiff, tired and uncoordinated. I realize my disease has advanced in the last 10 years, but I do expect to regain some leg functionality in the next year as my body learns to manufacture and process dopamine on its own again. From what I have read this can take over a year. But there is little info out there.

Has anyone else on this board quit Sinemet and / or Mirapex, and does anyone have any idea as to the timeline I am looking at to reestablish a normal dopamine system?

Apparently not too many non-Parkinson's people are "lucky" enough to get this rx, and fewer ever quit.

Thanks!

You might try the Parkinson's board for info about Sinemet and Mirapex....many have changed meds there and discontinued them or changed the doses.

http://neurotalk.psychcentral.com/fo...sprune=-1&f=34

I don't know how many MSers have used these drugs, but you
can ask there too.

http://neurotalk.psychcentral.com/fo...sprune=-1&f=17