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Cladrabine (oral pill) delayed - delay not quantified

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Old 11-30-2009, 10:20 AM #1
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Default Cladrabine (oral pill) delayed - delay not quantified
http://www.bloomberg.com/apps/news?p...d=aiWakRM_EOoA

“Our next step is to request a meeting with the FDA,” said Schrimpf in a telephone interview. “We’re not in a position to discuss the details of the FDA letter.”
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Old 11-30-2009, 04:07 PM #2
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Thanks for the link...the types of cancer that were found in patients in the trial are kind of scary, IMHO...
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Old 11-30-2009, 04:58 PM #3
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This is the one my neuro spoke about as a possibility for me. He said that the people who got cancer had already had cancer before so he said it couldn't absolutely be attributed to the Cladribine.

I wonder how many patients were in the trial, including those on placebo? And were any of the placebo patients cancer survivors? I'd like to get all the details about this.
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Old 11-30-2009, 06:10 PM #4
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Wow, that's a serious disappointment for those people whose options are slim and were really looking forward to pills. Cancer of the placenta sounds quite bizarre--surely something that odd (rare?) is a drug side effect?

Cladribine never appealed to me because of the cancer stuff--I do find that scary. But I guess Fingolimod, the other potential oral MS drug, also has some skin cancer risks (melanoma).
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Old 11-30-2009, 06:12 PM #5
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Tysabri has also been linked to Melanoma.
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Old 11-30-2009, 07:01 PM #6
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I am simply not interested in anything, including Meds, that suppresses my Immune System. I realize that in the short term, they may help to slow MS, but, at what cost. How can suppressing the immune system,long term, ever be a good thing?
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Old 12-01-2009, 01:58 AM #7
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Hi Wiz, yes I know that Tysabri has been linked to melanoma but only 2 cases, right? And these were post-marketing? I think fingolimod has been linked to 6-7 cases of skin cancer in the clinical trials. Regardless, Sally is right on the money when she points to the dangers of suppressing the immune system.

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Tysabri has also been linked to Melanoma.
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