....and I am so tired, and sore, and tingly, and muscles going crazy. When can I expect a GREAT change for the better. So far, 'sometimes' I feel a little better and sometimes I don't feel better at all.

Is there ever a time when ms symptoms do not respond to steroids? and if so, what does that mean?

I think it depends on the person. We did 3 rounds of 5 day IVSM and 7 rounds of oral steroids last year and the final round of IVSM was to prove that steroids do not work for me at all. Aside from making me extremely ill, and causing a few too many blown veins they seemed to have no effect or a worsening effect for me. My very first round on my very first day I woke up actually feeling my legs, and my feet and it was great....then the second round made me sick and it was downhill from there.

After the last round the neuro vowed never to give me Solumedrol ever again... which works out pretty good with the decision to start the TY.

BUT... Other people respond wonderfully, and some people respond a few days after stopping, so like everything else with this darn disease I think it is a wait and see game.

Thank you. I will hold out on hope. It's all I've got right now. I did finally get a few hours of good sleep tonight. Sleep does wonders for me. Hopefully I will continue to get lined out. Sometimes I just get too discouraged and lose hope. That is too bad that they quit working for you. It's just hard to tell where the progression of the disease is going to take us.

Hugs!