NeuroTalk Support Groups - estrogen and me.

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- - estrogen and me. (https://www.neurotalk.org/multiple-sclerosis/132877-estrogen.html)

Whew! I feel for you Dej. :( Remember when I was going through the "change" (HA!) I'd be sleeping so well and all of a sudden the heat would start building until I'd throw off all the covers and whip off my T-shirt! Unbelievable!

Doesn't our MS cause our internal thermostats to go crazy? I wonder if that has anything to do with this? Good luck finding a way to chill! :)

We dont normally eat at restaurants. Maybe once a month or two we eat at a local place that makes home made food. I may be getting soy in there some where, but 99% of what I eat is home made by my hands.

my CRP or C reactive protien is always above 10 and has been known to bump 18. Its a measure of inflammation in your body, and they use it on normal folks to measure your risk of heart attack and stroke. If you have sprained your ankle it will soar, or if you have MS it will soar. under 5 is optimal. 7 to 9 and they put you at high risk for an event. over 10 they start to consider other factors like a fracture, arthritis, or MS.

For the last few days this whole hot/cold thing has swung out of control. Im hot enough to sweat, then 10 mins later I am cold enough to have goose bumps and chills. bizarre! then again, we are talking about me tho.

I just did a huge battery of blood tests and all were normal. My thyroid is flat and even. my LFTs were normal, my white/red counts all normal. my chest xray was normal. My urine test was normal. They even cultured it to be sure. I am wondering if my body isnt just over reacting to a bug after being on copaxone for 3 years, and now being off of it. I wonder if my body isnt learning how to balance.

ok, now im hot...:(

That is a really high C-reactive protein!

Mine jumped from .5 to 1.5 during a root canal procedure!
My doctor was alarmed. She says anything over 1.0 is serious.

One can reduce C-reactive protein with Vit C!
Here is a study on that:

Quote:

Free Radic Biol Med. 2009 Jan 1;46(1):70-7. Epub 2008 Oct 10.
Vitamin C treatment reduces elevated C-reactive protein.

Block G, Jensen CD, Dalvi TB, Norkus EP, Hudes M, Crawford PB, Holland N, Fung EB, Schumacher L, Harmatz P.

University of California, Berkeley, 94720, USA. gblock@berkeley.edu
Abstract

Plasma C-reactive protein (CRP) is an inflammatory biomarker that predicts cardiovascular disease. Lowering elevated CRP with statins has reduced the incidence of cardiovascular disease. We investigated whether vitamin C or E could reduce CRP. Healthy nonsmokers (N=396) were randomized to three groups, 1000 mg/day vitamin C, 800 IU/day vitamin E, or placebo, for 2 months. Median baseline CRP was low, 0.85 mg/L. No treatment effect was seen when all participants were included. However, a significant interaction was found, indicating that treatment effect depends on baseline CRP concentration. Among participants with CRP indicative of elevated cardiovascular risk (> or =1.0 mg/L), vitamin C reduced the median CRP by 25.3% vs placebo (p=0.02) (median reduction in the vitamin C group, 0.25 mg/L, 16.7%). These effects are similar to those of statins. The vitamin E effect was not significant. In summary, treatment with vitamin C but not vitamin E significantly reduced CRP among individuals with CRP > or =1.0 mg/L. Among the obese, 75% had CRP > or =1.0 mg/L. Research is needed to determine whether reducing this inflammatory biomarker with vitamin C could reduce diseases associated with obesity. But research on clinical benefits of antioxidants should limit participants to persons with elevations in the target biomarkers.

PMID: 18952164 [PubMed - indexed for MEDLINE]PMCID: PMC263157

Eating smaller meals, more often may help. This controls insulin release. Avoidance of sugar, caffeine, alcohol may help with sweating too. See if eating a small protein dense snack (with low carb content) before bedtime, helps some. That would point you in the metabolic direction.

Heavy sweating may be:
1) hormonal
2) metabolic (pancreas, thyroid)
3) dietary (sugar highs/lows)
4) inflammatory/infectious
5) drug induced -- many drugs cause sweating

Dej,
Maybe you are thinking of the ESR test, not the C-Reactive Protein test. The ESR blood test, stands for erythrocyte sedimentation rate. It is a test that indirectly measures how much inflammation is in the body. That level can vary to the numbers you quoted.

I have had 7, and at one point 78 ESR, then 29 another time, all in the past.

My CRP was normal, the two times I was tested for it, again in the past.

Just a thought.:)

nope, my ESR is 37.
My CRP is 14 last check. (my md assures me its MS inflammation causing this)

btw, it turns out that our house had a bug of some sort. Hubby is crabbing about being hot/cold/hot/cold/sweaty/shakey...so, I am giving this a few more days.

I did notice last night, while I woke hot, I was not drenched in sweat. That was a pleasant change. I am going to hold out hope that estrogen replacement in such a tiny dose will fix me right up. its just wierd to go this long with no estrogen only to find myself changing at the right time. I wonder if all that endometrial tissue spread out in my tummy is holding onto estrogens from foods. weird, weird weird.

I would just like to add: .5mg (500mcg) is not a tiny dose.

Estradiol comes orally in .5mg (500mcg), 1mg and 2mg for hormone replacement. .5mg just happens to be the smallest of the 3 doses used for hormone replacement. The patches for this drug bypass the liver and are much lower in dose. They are in the microgram range.

Compared to most birth control pills which have about .035mg of estradiol which is 35mcg. (Ortho Cyclen) or like the newer Yaz which is 20mcg, and LoEstrin which is 20mcg also.

I believe that the .5mg dose is a considerable amount of potent estrogen (estradiol is the most potent biologically active form).