Pharmacologically speaking.... both stimulants can be useful when used carefully.

Their biggest drawback is that if used every day...
tolerance can occur necessitating higher doses. So medication "holidays" can help prevent that.

Secondly these do affect the heart and blood pressure so anyone with heart issues, or high blood pressure may have issues of safety, there.

Thirdly, long term use of these can result in depression. This has to due with depletion of neurotransmitters in the brain.
Typically the wearing off period during the day, can be a huge "crash" for some people. Here again using occasionally or having "holidays" may help prevent this side effect.

But used carefully with doctor monitoring (blood pressure and cardiac EKGs etc) many people find them helpful. Some Parkinson's patients use them.