Multiple Sclerosis

jackD · 03-08-2012, 12:33 AM

I take (Pine Bark Extract) PBE -> PYCNOGENOL 100 mg Twice a day.

Cured my psoriasis. My brother used it and it worked for him also.

jackD

Quote:

Phytother Res. 2001 Feb;15(1):76-8.

From ancient remedies to modern therapeutics: pine bark uses in skin disorders revisited.

Rihn B, Saliou C, Bottin MC, Keith G, Packer L.
SourceMembrane Bioenergetics Group, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA.

Abstract
The effect of French maritime pine bark extract (PBE) on the gene expression profile of HaCaT human keratinocytes was studied using high density filter arrays. The expression profile of both control and PBE-treated cells was determined. Interestingly, PBE was shown to downregulate both calgranulin A and B genes which are known to be upregulated in psoriasis and various dermatoses. Thus, PBE could be considered in human dermatoses.

Copyright 2001 John Wiley & Sons, Ltd.

PMID:11180529[PubMed - indexed for MEDLINE]

Quote:

Free Radic Biol Med. 2000 Jan 15;28(2):219-27.

Pine bark extract pycnogenol downregulates IFN-gamma-induced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-1 expression.

Bito T, Roy S, Sen CK, Packer L.
SourceDepartment of Molecular and Cell Biology, University of California, Berkeley 94720-3200, USA.

Abstract
Expression of intercellular adhesion molecule-1 (ICAM-1) is necessary for leukocyte/keratinocyte interactions. Upregulation of ICAM-1 expression in keratinocytes has been observed in several inflammatory dermatoses, such as psoriasis, atopic dermatitis, and lupus erythematosus. Inflammatory cytokines, such as interferon-gamma (IFN-gamma), upregulate ICAM-1 expression in keratinocytes. Because of potent antioxidant and anti-inflammatory properties of the French maritime pine bark extract, Pycnogenol (Horphag Research, Geneva, Switzerland), its effects were investigated on the interaction of T cells with keratinocytes after activation with IFN-gamma and the molecular mechanisms involved in such interactions. Studies were performed using a human keratinocyte cell line, HaCaT. Cell adhesion in the presence of IFN-gamma was studied using a coculture assay. Treatment of HaCaT cells with 20 U/ml IFN-gamma for 24 h markedly induced adherence of Jurkat T cells to HaCaT cells. PYC pretreatment (50 microg/ml, 12 h) significantly inhibited IFN-gamma induced adherence of T cells to HaCaT cells (p < .01). ICAM-1 plays a major role in the IFN-gamma-induced adherence of T cells to keratinocytes.

Thus, the effect of PYC on IFN-gamma-induced ICAM-1 expression was investigated as well. Pretreatment of HaCaT cells with PYC significantly inhibited IFN-gamma-induced expression of ICAM-1 expression in HaCaT cells. The downregulation of inducible ICAM-1 expression by PYC was both dose and time dependent. A 50 microg/ml dose of PYC and a 12 h pretreatment time (i.e., before activation with IFN-gamma) provided maximal (approximately 70%) inhibition of inducible ICAM-1 expression in HaCaT cells. Gamma-activated sequence present on the ICAM-1 gene confers IFN-gamma responsiveness in selected cells of epithelial origin (e.g., keratinocytes) that are known to express ICAM-1 on activation with IFN-gamma. Gel-shift assays revealed that PYC inhibits IFN-gamma-mediated activation of Stat1, thus suggesting a transcriptional regulation of inducible ICAM-1 expression by PYC.

These results indicate the therapeutic potential of PYC in patients with inflammatory skin disorders.

PMID:11281289[PubMed - indexed for MEDLINE]

http://radio.about.com/od/thanksgivi...ideo-Audio.htm

SallyC · 03-08-2012, 11:53 AM

Quote:

Originally Posted by SallyC

Hi Leslie, welcome to Neurotalk.

That sounds like Shingles to me. Have you seen your Doc?

OK, so what do I know...It was a good guess..lol

EddieF · 03-09-2012, 01:23 PM

Pine Bark as jackD & Dr Oz mentioned it.
Tea Tree Oil is my 2 cents which may also increase estrogen (which is why I tried it).
UV rays from good ol sunshine should help as well since its method of new device used for skin condition mentioned.

Debbie D · 03-09-2012, 05:48 PM

My eldest son had really bad eczema when he was small...his scabs would drain.
My dad had bad psoriasis...his patches would occasionally drain.

Either way, sounds like good advice on this thread...

agate · 03-09-2012, 08:28 PM

Quote:

Originally Posted by Leslie Werner

Hi,
I have had MS for 20 years now. Four years ago, I developed lesions that are very painful, on my scalp. They seem to travel in nerve pathways, and they seep and in the morning, the seepage has turned to crystals which feel like bits of glass. I have doctored for this with no success. Has anyone had this happen to them?

Hi Leslie,

I'm stumped. I've never heard of anything like this, and I've had eczema. The part that really puzzles me is this: "The seepage has turned to crystals which fell like bits of glass."

I hope you're seeing a good doctor about this. It sounds like a nightmare. I hope there's a remedy.

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