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Old 07-15-2012, 07:05 AM #1
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mrsD mrsD is offline
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mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb Replacing key lipids (fatty acids) in MS for myelin:

This is a recent article in Science News regarding using
replacement of 4 key lipids to help remyelination:

http://www.sciencenews.org/view/gene...s_may_fight_MS

(I hope this link works, as I have a membership) Science News has opened its online access to non members recently.

This is the core of the article in case you cannot link to it:
Quote:
Steinman and his colleagues conducted tests in mice with a condition similar to MS and found that injections of the lipids over several weeks could limit severity of the disease and even reverse some symptoms in the animals. The four lipids — abbreviated as PGPC, azPC, azPC ester and POPS — share a similar phosphate group, to which the rogue antibodies bind.

Other tests in mice showed that side chains of fatty acids, attached to the lipids like fingers on a glove, “keep the myelin-making cells alive and reduce the inflammatory response,” Steinman says. “It turns out that the side chains are imbued with protective properties.” They repel inflammation and even kill the T cells that trigger it, the researchers found...It could be that people with MS, who lack adequate supplies of these lipids and their protective fatty acids, fail to keep up with the destruction caused by antibodies and inflammation.
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