I believe that MS is caused by missing enzymes in the pancreas called protease and DNase1. Protease and DNase1 break down dietary proteins and DNA. You can literally trace every symptom and every valid scientific finding in MS back to these missing enzymes.

I was diagnosed with lupus, CFS and fibromyalgia over 20 years ago. It was when I happened on a study done in Germany that stated lupus patients lack the enzyme DNase1 that eventually led me to understand that every symptom and valid scientific finding in not only lupus, but in fibromyalgia, CFS, Sjogrens, RA, hypothyroidism, and MS could be traced back to these missing enzymes. In fact, I believe that the evidence will show that these are all just different manifestations of one disease-Pancreatic Enzyme Deficiency Disease (PEDD).

I hope to be able to show how every symptom and valid scientific finding in MS can be traced "directly" back to these enzymes. Also, if these diseases originate with PEDD, then their symptoms and findings should be the same. For instance, if PEDD leads to autonomic nervous system dysfunction, spinal cord degeneration, white matter lesions, elevated homocysteine, dysregulated tumor necrosis factor,low vitamin B12, low iron, etc. then all of these diseases should share these same symptoms and findings.

Hello Annesse and welcome to Neuro-talk.

While there are many theories with respect to the cause of MS and other auto-immune diseases, I had not heard of the protease and DNase1 connection; although similar claims were and are made with respect to lipase, the enzyme that helps to metabolize fats, cholesterol and essential fatty acids.
While these theories may have some validity, as with other diseases involving immune system dysfunction, like cancer and allergies, it seems that metabolic errors of this sort may be a contributing factor or condition, rather than a singular cause. Despite the extensive search for a single common cause, one has yet to be established; although I sincerely wish you all the best in your endeavor to do so.

Typically when we look at any result there is a process and protocol as it were to be followed; at least with respect to scientific research. The theory behind that protocol has stood the test of time and is as follows.

'When a cause and condition come together there is a predictable result. Therefore both the causes and conditions must be discovered if one is to gain a full understanding of the result.'
In this case the result is auto-immune disease, including MS.

The difference between cause, condition and result can most easily be appreciated if the three are examined rather simplistically.
For example, in the case of a bean sprout, we can see that the cause of the sprout is the bean seed; for if that cause did not exist, there could be no sprout. Yet the bean seed does not become a sprout until it meets with certain conditions. So it can also be appreciated that the conditions alone will not produce a bean sprout if the cause is not also present in the form of a bean seed.
It is only when both the cause (the bean seed) and the conditions (moisture, warmth, fertile soil and light) come together that the resultant effect (a bean sprout) is produced.

Getting back to auto-immune disease, despite extensive research to find a common cause, one has yet to be established, but many theories have gained popular acceptance; at least as far as propensity goes. This propensity theory simply means that there may be a common causation for how certain diseases manifest in individuals. In the case of auto-immune disease, the propensity is an alteration of the immune system function that is often accompanied by inflammation.
The proposed 'common propensity cause theory' seems to be leaning primarily toward genetics.

If it turns out that genetics is the cause of auto-immune disease, we are still left to figure out what the conditions are that might 'turn on' the gene cause; or to promote the seed to become a sprout, if we use the example given.
Research to date indicates that these conditions seem to be many and include stress, climate, vaccination, immune challenges, infections, nutritional deficiencies and metabolic errors.
What you are proposing, specifically that of a metabolic error as a cause of auto-immune disease, may actually fall into the latter category of conditions; things that may meet with the cause to produce the effect of auto-immune disease.

It seems that just like the process of a bean seed turning into a sprout, in the case of auto-immune disease, it is likely that more than one condition might also be needed to produce the resultant effect. Thus in keeping with your mention of a protease and DNase1 connection, it is also likely that more of the other conditions mentioned above, or even some, as of yet unknown conditions, must also be present along with such a deficiency to produce the resultant disease.

By supporting, cooperating and sharing ideas with each other, as well as with researchers and those who treat the symptoms of disease, just as you have, eventually it will be figured out. We must also remain open to the different theories of others as they present, so that all things are taken into consideration and carefully analyzed.
Then we will be in a better position to do so again when it comes time to figure out how best to interfere with either the cause or the conditions in order to prevent the resultant effect of disease.

As it is now however, just trying to figure out what the causes and conditions are and how they combine to produce the result of MS (and other disease as well), is the sort of thing that drives those involved in research nuts.
On a more personal level, this has been my struggle too.


With love, Erika

Erika! you blew me away! thanks.

I am always happy to hear theories, explanations, and ideas on how and what causes this stupid disease. The thing is after years and years of being told "its this!" or "nope, we found out its that!" you tend to be gun shy of the information.

I just hope they find out how to fix it, and QUICK!

Yes Erika, thank you for your reply. Your concerns were very well stated. I think I will be able to account for all of the things you mentioned. I am hoping to show that the disease process is a pathway that originates with PEDD. There are numerous ways this pathway can be interrupted, many of which you mentioned.

I liked your analogy of the bean sprout. This is much like the PEDD Pathway. I do think the cause and effect with PEDD is well defined. Much like an ulcer resulting from H pylori or gout resulting from high levels of uric acid.

I am going to list symptoms and findings in MS, and then show how they would be a direct result of missing pancreatic enzymes. I want to include every symptom and finding, so if I miss any please let me know. We will even include overlapping diseases.

White matter lesions
Optic neuritis and other vision complications
Ataxia, vertigo and other coordination and balance problems
Dysregulated iron
Low B12
Low vitamin D
Bowel and bladder problems
Restless leg syndrome
Muscle atrophy
Lack of glutathione
Low human growth hormone
Low tryptophan
Lack of essential amino acids, such as phenylalanine, leucine, valine, etc.
Depression
Dementia
Cognitive dysfunction
Fatigue
Sleeping difficulties
L'Hermitte's
Paraesthesia
Trigeminal neuralgia
Hormone imbalances, such as low testosterone
Increased risk of developing hypothyroidism
Increased risk of diabetes
Increased risk of Sjogrens
Heat Intolerance
Increase risk of developing certain types of cancer, such as lymphoma
Migraines
Vascular complications
Elevated tumor necrosis factor
Swallowing problems
Epileptic seizures
Autonomic nervous system dysfunction
Spinal cord degeneration
Mitochrondrial dysfunction
Lack of noradrenaline
Reason why gout and MS are almost mutually exclusive
Chronic itching

Please feel free to add to this list.

Tongue in cheek of course...

skepticism
being misunderstood
being misdiagnosed

I look forward to reading on what you base your assertions though.

With love, Erika

Erika, you took the words right out of my brain, but ever so eloquently..

Are these missing enzymes a cause or result of the disease? Still, it seems logical that, somehow replacing these enzymes would/should only help us.

How do you propose that we do this Annesse?

Welcome and be well.

Hi SallyC, first I have to provide convincing evidence that MS patients lack these enzymes. I believe that MS is a direct result of these missing enzymes. The disease is actually PEDD. The symptoms are what someone with MS, lupus, CFS etc. would experience. I think once you see all of the evidence, you will agree that the only safe and effective way to resolve this is through diet.

What an interesting and stimulating conversation!

I would like to share at the outset that my skepticism arises from a little personal experience; yet I am genuinely interested in learning about the theory and basis of it in this situation.

Due to having regional enteritis and having undergone surgery to remove and bypass sections of intestine, I ended up with peritonitis, hepatitis and secondary pancreatitis. The affect on pancreatic function was quite severe and so for around 6 months I was required to take pancreatin and additional digestive enzymes as well.

Now admittedly, I do not know if 'DNase1' was in the mix, or if there is a suggested protocol for taking the replacement enzymes in this case; but I do know that protease was in the mix that I was given; both through intubation and then orally.

Did it have an affect on my MS, hypothyroidism or even the regional enteritis? No.

These symptoms of auto-immune disease were all very much active before surgery, during recovery and remained so even once the peritonitis infection and organ inflammations were brought under control, and I continued with the enzyme replacement.

Again, I think it is important to remain open to, as well as to analyze with careful scrutiny all ideas; but I do have a resistance to 'single answer theories'. The resistance is based on a personal belief that although symptoms may be similar when comparing both individuals and diseases, that we are all individuals with individual genetics, conditions and circumstances etc; and that the similarities of symptoms are more due to the fact that we have in common a human body that reacts in relatively predictable ways; such as inflammation.

Yet, I am listening...

With love, Erika

AMEN, you little rascal..

QUOTE:
"I hope to be able to show how every symptom and valid scientific finding in MS can be traced "directly" back to these enzymes.

I am going to list symptoms and findings in MS, and then show how they would be a direct result of missing pancreatic enzymes. I want to include every symptom and finding, so if I miss any please let me know. We will even include overlapping diseases."

I'm also curious to learn about the reason or motivation for this undertaking; of 'hoping to show...'
Is the interest a personal, professional, academic one or...?

Also who is the "we" that is being referred to in the last statement? Is there a research body that is having a look at this, and if so, might there an internet link to them?

With love, Erika