After the miserable fail of Copaxone, my neurologist and I sat down and discussed treatment options yesterday. I had had an allergic reaction to Copaxone in July after 5 injections, my neurologist ordered me to stop them. We discussed Tecfidera, but my neurologist decided against it since I already have chronic nausea. He ruled out Extavia because of the injection frequency. We settled on Plegridy since it is a single injection every 14 days. I am very sensitive to medications, at least that's what they tell me...lol... I was hoping someone may have tried Plegridy and could give a little insight.

I have not tried it. Hopefully, someone who has tried it will come along and post.

I started on the 12th of August. Just had my first full dose on the 9th this month. The first 2 injections I had no reaction at all. I felt good but I did take ibuprofen and tylenol on a schedule for 2 days after.

The first full dose went well too as far as the injection with no injection site reaction at all and no pain. I didn't remember to take the ibuprofen and tylenol on schedule the last time, not sure why I didn't, I just got busy the next day and forgot to medicate. So Saturday night while attending a wedding, the side effects hit. I had the aches and felt sick to my stomach but the worse part was that it felt like all my MS symptoms got worse. I could hardly walk! We left the wedding and I didn't think I was going to make it to the car. I had forgot to replenish my ibuprofen in my purse.
Once I made it into the house (wasn't sure I was going to make it up 2 steps into the house from the garage) and took ibuprofen and laid down for an hour, I started to feel a little better.

I took medication for the next 3 days and I am doing okay. I did get a flu shot this Friday and now today I have symptoms back again. Not sure if it is from the flu shot or still from the Plegridy.

I have been on Copaxone for the past 2 years and went to Plegridy because I have been slowly progressing and wanted something stronger to try to stop the progression.

Hope this helps. Good luck!

My3sons, Thanks for the input...I feel better about it now. My starter kit will be delivered tomorrow and I am in the middle of packing to move this weekend. What a week!