I was on methotrexate shots for about a year in combination with Betaseron to treat my MS. I titrated up from .4 cc to 1 cc over a period of 4 months and was sick each week the day of the shot. Flu-like symptoms and then each titration I was sicker...

The purpose of the MTX was to break the exacerbation cycle I was in. I was having exacerbations every 3 months. After the year, it didn't work and I was so sick that the rheumy that was monitoring me decided that it just wasn't worth it. My white count was hovering at the low normal level and my platelet count had started to decrease.

They also had me take folic acid along with the MTX.

I know that there are a lot of people who take MTX for MS therapy and have had good luck with it...I just wasn't one of those people...I happen to be one of those med sensitive people.

I think Kinch52 takes it...and you might want to post something on the medications forum asking about it as well.